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All 51 undifferentiated NPCs contained significant numbers of EBV\u2010genome copies per cell. Two of the somewhat differentiated NPCs were also EBV\u2010DNA\u2010positive, whereas 2 were negative. Of the 7 other nasopharyngeal tumors, 1 was EBV\u2010DNA\u2010positive. Histological examination, however, showed that this was a typical Burkitt lymphoma. The other 6 tumors were all EBV\u2010DNA\u2010negative lymphoproliferative malignancies. All 14 head and neck carcinomas located outside the nasopharynx were EBV\u2010DNA\u2010negative. The sera of undifferentiated NPC patients had elevated antibody titers against the EBV\u2010determined antigens, the EA (D) component in particular. These findings confirm that there is a regular association between EBV\u2010DNA and undifferentiated NPC.<\/jats:p>","DOI":"10.1002\/ijc.2910200403","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:06:24Z","timestamp":1171904784000},"page":"486-494","source":"Crossref","is-referenced-by-count":146,"title":["Relationship between the Epstein\u2010Barr virus and undifferentiated nasopharyngeal carcinoma: Correlated nucleic acid hybridization and histopathological examination"],"prefix":"10.1002","volume":"20","author":[{"given":"Maria","family":"Andersson\u2010Anvret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Forsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"129","volume-title":"Epstein\u2010Barr virus, production, concentration and purification","author":"Adams A.","year":"1975"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(76)90064-7"},{"key":"e_1_2_1_4_1","volume-title":"Viruses and human cancers","author":"Andersson\u2010Anvret M.","year":"1977"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100003856"},{"key":"e_1_2_1_6_1","first-page":"443","article-title":"Epstein\u2010Barr virus\u2010associated antibody patterns in carcinoma of the post\u2010nasal space","volume":"5","author":"De Schryver A.","year":"1969","journal-title":"Clin. exp. 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