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The EBV\u2010trans\u2010formed lymphoblasts and SV40\u2010transformed fibro\u2010blasts were grown as continuous cell lines and expressed the same histocompatibility antigens as tumor cell lines established from the same cancer patients. Sera from 350 melanoma and 195 sarcoma patients were tested for antibody reactive with membrane antigens on three of these tumor cell lines (two melanomas and one sarcoma) by immune adherence (IA) and indirect immunofluorescence (IMI) assays. Antibodies to HLA and other non\u2010tumor\u2010related antigens were completely removed from the most reactive sera by quantitative absorption with 4 \u00d7 10<jats:sup>7<\/jats:sup> lymphoblasts or 10<jats:sup>7<\/jats:sup> transformed fibroblasts autologous to the tumor target cells. These paired cell lines were used to monitor humoral immune responses in melanoma and sarcoma patients receiving allogeneic tumor cell vaccines.<\/jats:p>","DOI":"10.1002\/ijc.2910210308","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:01:13Z","timestamp":1171904473000},"page":"299-306","source":"Crossref","is-referenced-by-count":21,"title":["Establishment of paired tumor cells and autologous virus\u2010transformed cell lines to define humoral immune responses in melanoma and sarcoma patients"],"prefix":"10.1002","volume":"21","author":[{"given":"R. E.","family":"Saxton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Irie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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