{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:18:18Z","timestamp":1758280698754},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9955,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1979,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spleen cells (SC) both from BALB\/c mice whose primary Moloney sarcoma virus (MSV)\u2010induced sarcomas had spontaneously regressed and from normal, untreated BALB\/c mice, were co\u2010cultivated for 5 days with mitomycin\u2010C\u2010treated LSTRA cells; LSTRA is a BALB\/c Moloney lymphoma which shares cell surface antigens with MSV\u2010induced sarcomas. These SC, referred to as CMR and CU cells, respectively, were shown to be cytotoxic to LSTRA cells in 3 h <jats:sup>51<\/jats:sup>Cr\u2010release assays; CMR cells showed, in most cases, the greatest lytic activity against LSTRA targets. The same SC were also reactive, in 20\u2010h microcytotoxicity and <jats:sup>51<\/jats:sup>Cr\u2010assays, against target cells from a variety of transplanted sarcomas induced by 3\u2010methylcholanthrene (MCA) in BALB\/c mice. The highest reactivity was seen when CMR or CU cells were tested against target cells from sarcoma lines that expressed an NB\u2010ecotropic MuLV cross\u2010reacting serologically with Moloney virus. Reactivity against isotope\u2010labelled tumor cells expressing MuLV\u2010associated cell surface antigens could be competitively inhibited by adding unlabelled tumor cells expressing such antigens. Finally, Winn assays were performed in which CMR cells strongly inhibited the outgrowth of cells from three sarcoma lines that express the NB\u2010ecotropic MuLV. There was less but significant inhibition of cells from some other MCA sarcomas, either negative for the expression of MuLV\u2010associated antigens or expressing the N\u2010ecotropic endogenous BALB\/c MuLV. CU cells enhanced tumor outgrowth in Winn assays at least as often as they inhibited it.<\/jats:p>","DOI":"10.1002\/ijc.2910230418","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:48:01Z","timestamp":1171907281000},"page":"555-564","source":"Crossref","is-referenced-by-count":10,"title":["Cell\u2010mediated reactivity to antigens shared by moloney\u2010virus\u2010induced lymphomas (LSTRA) and certain 3\u2010methylcholanthrene\u2010induced mouse sarcomas"],"prefix":"10.1002","volume":"23","author":[{"given":"I.","family":"Hellstrom","sequence":"first","affiliation":[]},{"given":"K. E.","family":"Hellstrom","sequence":"additional","affiliation":[]},{"given":"L.","family":"Zeidman","sequence":"additional","affiliation":[]},{"given":"I. D.","family":"Bernstein","sequence":"additional","affiliation":[]},{"given":"J. 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