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Among 12 undifferentiated NPCs, 11 were positive for EBV\u2010DNA, with multiple copies of the viral genome per cell. Serological tests showed elevated anti\u2010VCA and anti\u2010EA (DA) titers. Six NPCs with various degrees of squamous differentiation, four malignant lymphomas of the nasopharynx and seven carcinomas located outside the nasopharynx were EBV\u2010DNA negative. These findings further stress the uniqueness and regularity of the association between EBV\u2010DNA and undifferentiated NPC. Clearly, the association extends over geographical barriers and holds true not only in the previously studied, moderate\u2010incidence African ethnic group, but also in the low\u2010incidence Western patients.<\/jats:p>","DOI":"10.1002\/ijc.2910230605","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:45:55Z","timestamp":1171907155000},"page":"762-767","source":"Crossref","is-referenced-by-count":37,"title":["Relationship between the Epstein\u2010Barr virus genome and nasopharyngeal carcinoma in Caucasian patients"],"prefix":"10.1002","volume":"23","author":[{"given":"Maria","family":"Andersson\u2010Anvret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Forsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Bi\u00f6rklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"129","volume-title":"Epstein\u2010Barr virus, production, concentration and purification","author":"Adams A.","year":"1975"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/260357a0"},{"key":"e_1_2_1_4_1","first-page":"100","volume-title":"Viruses and human cancers, Progress in experimental tumor research","author":"Andersson\u2010Anvret M.","year":"1978"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200403"},{"key":"e_1_2_1_6_1","first-page":"443","article-title":"Epstein\u2010Barr virus\u2010associated antibody patterns in carcinoma of the post\u2010nasal space","volume":"5","author":"De Schryver A.","year":"1969","journal-title":"Clin. exp. 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