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In the lymphocyte culture with TPA (0.5 ng\/ml), the frequency of establishment of LCL increased and the time required for appearance of transformation decreased. A larger number of EBV\u2010positive cells in the peripheral blood were detected in the assay by co\u2010cultures with cord blood lymphocytes in the presence of TPA than in the absence of it. The enhancement of LCL establishment by TPA was largely abolished in the culture with EBV neutralizing antibody\u2010containing human umbilical cord serum. This suggests that the enhancement by TPA may be caused mostly by transformation of coresident B lymphocytes infected with active virus induced from the EBV genome\u2010positive cells by TPA.<\/jats:p>","DOI":"10.1002\/ijc.2910270206","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:18:49Z","timestamp":1171909129000},"page":"161-166","source":"Crossref","is-referenced-by-count":9,"title":["Enhancement of outgrowth of EB virus\u2010transformed cells from normal human peripheral blood by a tumor promoter, TPA"],"prefix":"10.1002","volume":"27","author":[{"given":"Hidehiko","family":"Yamamoto","sequence":"first","affiliation":[]},{"given":"Takato","family":"Katsuki","sequence":"additional","affiliation":[]},{"given":"Shinji","family":"Harada","sequence":"additional","affiliation":[]},{"given":"Yorio","family":"Hinuma","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1128\/jvi.2.7.663-669.1968","article-title":"Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis","volume":"2","author":"Diehl V.","year":"1968","journal-title":"J. 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