{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:33:28Z","timestamp":1760888008047},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8526,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1983,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibroblast\u2010like cells (F\u2010cells) and epithelial\u2010like (E\u2010cells) derived from cultures of rabbit VX\u20102 carcinoma released collagenase in both active and latent forms in serum\u2010free medium at a level higher than that of normal rabbit fibroblast cultures. The enhanced capacity of the F\u2010cells to release the enzyme, however, continued only for a few passages and then decreased significantly to a low level similar to that of the normal fibroblasts. The enzyme\u2010release by the E\u2010cells continued for a few more passages at a relatively moderate level, higher than that of normal fibroblasts. The release of collagenase in cultures of F\u2010cells was enhanced by the presence of E\u2010cells in mixed cultures as well as by medium conditioned by the E\u2010cells type. Addition of cytochalasin B at 2 \u03bcg\/ml did not significantly effect the enzyme activity released in the cultures. Serum from tumor\u2010bearing rabbits appeared to stimulate the release of enzyme activity in cultures of either cell type.<\/jats:p>","DOI":"10.1002\/ijc.2910310317","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:08:34Z","timestamp":1171912114000},"page":"357-364","source":"Crossref","is-referenced-by-count":30,"title":["Collagenase activity in rabbit carcinoma: Cell source and cell interactions"],"prefix":"10.1002","volume":"31","author":[{"given":"Mustafa Kh.","family":"Dabbous","sequence":"first","affiliation":[]},{"given":"Mahmoud","family":"El\u2010Torky","sequence":"additional","affiliation":[]},{"given":"Lena","family":"Haney","sequence":"additional","affiliation":[]},{"given":"Burchada","family":"Brinkley","sequence":"additional","affiliation":[]},{"given":"Nahed","family":"Sobhy","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(75)90243-0"},{"key":"e_1_2_1_3_1","first-page":"4594","article-title":"Enhanced collagenase production by fibroblasts derived from human basal cell carcinoma","volume":"39","author":"Bauer E. A.","year":"1979","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","article-title":"Separation of VX\u20102 rabbit carcinoma\u2010derived cells capable of releasing collagenase","volume":"38","author":"Dabbous M. Kh.","year":"1982","journal-title":"Exp. Mol. Path."},{"key":"e_1_2_1_5_1","article-title":"Cytogenetic analysis of collagenase\u2010releasing rabbit VX\u20102 carcinoma derived cells","volume":"7","author":"Dabbous M. Kh.","year":"1982","journal-title":"Cancer Genet. Cytogenet."},{"key":"e_1_2_1_6_1","first-page":"636","article-title":"Selectivity in matrix collagen degradation by tumor collagenases","volume":"41","author":"Dabbous M. Kh.","year":"1982","journal-title":"Fed. Proc."},{"key":"e_1_2_1_7_1","first-page":"3537","article-title":"Collagen and neutral protease activities in cultures of rabbit VX\u20102 carcinoma","volume":"37","author":"Dabbous M. Kh.","year":"1977","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(72)90895-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01769837"},{"key":"e_1_2_1_10_1","first-page":"933","article-title":"Collagenolytic enzymes in human neoplasms","volume":"32","author":"Dresden M. H.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.2.1176"},{"key":"e_1_2_1_12_1","first-page":"1063","volume-title":"Annual Reviews of Biochemistry","author":"Harper E.","year":"1980"},{"key":"e_1_2_1_13_1","first-page":"249","volume-title":"Proteinases in mammalian cells and tissues","author":"Harris E. D.","year":"1977"},{"key":"e_1_2_1_14_1","first-page":"2790","article-title":"Collagenolytic activities of squamous cell carcinoma of the skin","volume":"33","author":"Hashimoto K.","year":"1973","journal-title":"Cancer Res."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100207"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4417"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.9.5331"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.193181"},{"key":"e_1_2_1_19_1","first-page":"338","volume-title":"Lysosomes in biology and pathology","author":"Lazarus G. S.","year":"1973"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/58.5.1427"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(81)91886-6"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/284067a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(79)90109-2"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1520131"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90620-0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80444-4"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313028209061286"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280418"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.1.85"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1370373"},{"key":"e_1_2_1_32_1","first-page":"2551","article-title":"Effects of collagenolytic activity in basal cell epithelioma of the skin on reconstituted collagen and physical properties and kinetics of the crude enzyme","volume":"32","author":"Yamanishi Y.","year":"1972","journal-title":"Cancer Res."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910310317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910310317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:56:49Z","timestamp":1697759809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910310317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3,15]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,3,15]]}},"alternative-id":["10.1002\/ijc.2910310317"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910310317","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3,15]]}}}