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Six of the lines carried the variant translocations 8;2 or 8;22 (three each), 17 lines had the typical 8;14 translocation, I was translocation\u2010negative (BJAB) and 2 were not examined cytogenetically. Depending on their immunoglobulin and surface marker expression, the BL lines could be subdivided into several subgroups. There was a strong inverse correlation between the expression of the CALLA and the LB\u2010I marker. All BLA\u2010lines were CALLA\u2010, whereas the CALLA+ lines could be either BLA\u2010 or BLA+. All six variant translocations belonged to the CALLA\u2010BLA\u2010LB\u2010I + category. Only one set of three lines, derived from the patient with the 8;14 translocation, belonged to the same subgroup. This suggests that the typical vs. the variant translocation freezes the BL cell at a different stage of differentiation. The variant translocation\u2010carrying subtypes represent probably a somewhat more advanced stage of differentiation.<\/jats:p>","DOI":"10.1002\/ijc.2910330407","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:57:09Z","timestamp":1171915029000},"page":"459-463","source":"Crossref","is-referenced-by-count":30,"title":["Distinction between burkitt lymphoma subgroups by monoclonal antibodies: Relationships between antigen expression and type of chromosomal translocation"],"prefix":"10.1002","volume":"33","author":[{"given":"Barbro","family":"Ehlin\u2010Henriksson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90039-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90138-3"},{"key":"e_1_2_1_4_1","unstructured":"Barger R. andBernheim A. Cytogenetics of Burkitt lymphoma\u2010leukemia.IARC Monographs in press."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01008574"},{"key":"e_1_2_1_6_1","unstructured":"Croce C. M. Thierfelder W. Erikson J. Nishikura K. Finan J. Lenoir G. Rabbitts T. andNowell P. C. Transcriptional activation of an unrearranged and untranslocated c\u2010myc oncogene by translocation of a CLD locus in Burkitt lymphoma.Proc. Nat. Acad. Sci. (Wash.) in press."},{"key":"e_1_2_1_7_1","first-page":"547","article-title":"Morphological and virological investigations on cultured Burkitt tumor lymphobtasts (strain Raji)","volume":"37","author":"Epstein M. A.","year":"1966","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_8_1","unstructured":"Erikson J. Nishikura K. Ar\u2010Rushdi A. Finan J. Emanuel B. Lenoir G. Rabbitts T. Nowell P. C. andCroce C. M. Translocation of an immunoglobulin <locus to region 3' of an unrearranged c\u2010myc oncogene enhances c\u2010myc transcription.Proc. nat. Acad. Sci. 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