{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:46:29Z","timestamp":1770504389163,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An ouabain\u2010 and thioguanine\u2010resistant subline (TIKAUT) of spontaneous AKR lymphoma, TKA, was trisomic for chromosome 15 and contained a single 33 kb EcoRI fragment, containing the oncogene <jats:italic>c\u2010myc<\/jats:italic>. The original TKA lymphoma and derived <jats:italic>in vitro<\/jats:italic> line contained the same 33 kb fragment, as well as a normal 22 kb fragment. It has been concluded that the original 15\u2010trisomic TKA tumor has duplicated a 15\u2010chromosome that contained the changed fragment, while maintaining the normal fragment as well. Subsequently, in the derived TIKAUT line, the changed chromosome duplicated again, giving rise to three copies, and the normal homologue was eliminated altogether. This confirms our earlier somatic hybrid study showing that the duplicated 15\u2010chromosome of a T\u2010cell leukemia confers an advantage on the cell that favors tumorigenicity, whereas the normal homologue exerts a counteracting influence. Therefore, in the course of tumor progression, the changed chromosome tends to be amplified, whereas its normal homologue tends to be eliminated.<\/jats:p>","DOI":"10.1002\/ijc.2910330410","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:57:09Z","timestamp":1171915029000},"page":"477-481","source":"Crossref","is-referenced-by-count":32,"title":["Triplication of one chromosome no. 15 with an altered <i>C\u2010myc<\/i> containing ecori fragment and elimination of the normal homologue in a T\u2010cell lymphoma line of akr origin (TIKAUT)"],"prefix":"10.1002","volume":"33","author":[{"given":"Zvi","family":"Wirschubsky","sequence":"first","affiliation":[]},{"given":"Francis","family":"Wiener","sequence":"additional","affiliation":[]},{"given":"Jack","family":"Spira","sequence":"additional","affiliation":[]},{"given":"Janos","family":"S\u00fcmegi","sequence":"additional","affiliation":[]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.1982"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.22.6966"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.22.6994"},{"key":"e_1_2_1_5_1","first-page":"69","article-title":"Standard karyotype of the mouse","volume":"63","author":"Committee on Standardized Genetic Nomenclature for Mice","year":"1972","journal-title":"Mus musculus. J. Hered."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01407.x"},{"key":"e_1_2_1_7_1","volume-title":"Proc. International Congress of Immunology","author":"Cory S.","year":"1983"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.21.6497"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.4.1515"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.3.820"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(58)90039-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.13.4175"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90449-X"},{"key":"e_1_2_1_14_1","first-page":"305","article-title":"The evolution of independence from specific growth stimulation and inhibition in mammalian tumour cell populations","volume":"11","author":"Klein G.","year":"1957","journal-title":"Symp. Soc. Biol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(77)90052-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90137-4"},{"key":"e_1_2_1_17_1","first-page":"2609","article-title":"Non random chromosomal changes in Thy\u20101 positive and Thy\u20101\u2010negative lymphomas in\u2010duced by 7,12\u2010dimethylbenzanthracene in SJL mice","volume":"40","author":"Spira J.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280618"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90023-7"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6619"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/306497a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7837"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.3683"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio235052a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/61.1.227"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/275658a0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220413"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910330410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910330410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:04:12Z","timestamp":1697771052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910330410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4,15]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4,15]]}},"alternative-id":["10.1002\/ijc.2910330410"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910330410","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4,15]]}}}