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Selection for melanoma\u2010cell variants resistant to anti\u2010A CTL revealed that antigen A consists of at least 2 determinants (Aa, Ab) which can be lost separately. Genetic linkage between Aa and Ab was suggested by concomitant loss of Aa and Ab in an immunoselected tumor\u2010cell variant. This variant was also resistant to an autologous CTL clone restricted by HLA\u2010B45, indicating that this CTL may also recognize a determinant of antigen A. Of 11 allogeneic HLA\u2010A2 melanoma cell lines that were tested, 5 expressed both Aa and Ab, I expressed only Aa, and I only Ab. None of them was lysed by anti\u2010B or anti\u2010C CTL clones. A CTL clone derived from another HLA\u2010A2\u2010melanoma patient was found to have exactly the same lytic pattern as the anti\u2010Ab CTL of the first patient. This suggested that it may be possible to elicit an anti\u2010Ab response in many HLA\u2010A2 patients. We conclude that there are at least 2 distinct antigens presented in association with HLA\u2010A2 that are common to many melanomas and therefore constitute promising targets for specific immunotherapy.<\/jats:p>","DOI":"10.1002\/ijc.2910550212","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:44:50Z","timestamp":1171928690000},"page":"237-244","source":"Crossref","is-referenced-by-count":67,"title":["Analysis of antigens recognized on human melanoma cells by A2\u2010restricted cytolytic t lymphocytes (CTL)"],"prefix":"10.1002","volume":"55","author":[{"given":"T.","family":"W\u00f6lfel","sequence":"first","affiliation":[]},{"given":"M.","family":"Hauer","sequence":"additional","affiliation":[]},{"given":"E.","family":"Klehmann","sequence":"additional","affiliation":[]},{"given":"V.","family":"Brichard","sequence":"additional","affiliation":[]},{"given":"B.","family":"Ackermann","sequence":"additional","affiliation":[]},{"given":"A.","family":"Knuth","sequence":"additional","affiliation":[]},{"given":"T.","family":"Boon","sequence":"additional","affiliation":[]},{"given":"K. 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