{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:37:24Z","timestamp":1780511844371,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3923,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ninety\u2010eight cases of transitional\u2010cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type\u201016 and type\u201018 DNA by <jats:italic>in situ<\/jats:italic> hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 expression was also performed. Fresh tumor tissues from 26 patients were also studied for p53 mutations in exons 4 through 9 by direct sequencing and for HPV infection by polymerase chain reaction (PCR). Thirty\u2010two tumors were positive for HPV DNAs, including 6 double\u2010positive cases. Among these tumors, adjacent dysplastic lesions in 21 cases (66%) also revealed identical reactivity. Overexpressed p53 was detected in 26 cases. Expression of p53 was also detected in dysplastic lesions in 19 out of these 26 cases (73%). Three cases were positive for both HPV DNA and p53 antibody. p53 point mutation was detected in 7 of 26 cases, 6 of which were also positive for p53. HPV type\u201016 DNA was detected in 6 cases by PCR, 4 of which were also ISH\u2010positive. Overexpressed p53 was frequently detected in invasive and non\u2010papillary tumors (p &lt; 0.01) and in high\u2010grade tumors (<jats:italic>p<\/jats:italic> &lt; 0.05). HPV infection was more common in non\u2010invasive and papillary tumors (<jats:italic>p<\/jats:italic> &lt; 0.05). These findings suggest that HPV infection or overex\u2010pression (mutation) of p53 may be an early event and be related to phenotypes of tumor\u2010cell growth patterns and progression. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910640503","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:14:41Z","timestamp":1171934081000},"page":"298-303","source":"Crossref","is-referenced-by-count":14,"title":["p53 and human papillomavirus dna in renal pelvic and ureteral carcinoma including dysplastic lesions"],"prefix":"10.1002","volume":"64","author":[{"given":"Mutsuo","family":"Furihata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ohtsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sonobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotami","family":"Terao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morimasa","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuta","family":"Fujisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921001)70:7<1967::AID-CNCR2820700726>3.0.CO;2-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90662-M"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91595-D"},{"key":"e_1_2_1_5_1","first-page":"1389","article-title":"p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer","volume":"143","author":"Esrig D.","year":"1993","journal-title":"Amer. 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