{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:13:05Z","timestamp":1776053585642,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,10,2]],"date-time":"2003-10-02T00:00:00Z","timestamp":1065052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue engineering aims at resolving problems such as donor shortage and immune rejection faced by transplantation. Scaffolds (artificial extracellular matrices) have critical roles in tissue engineering. Recently, we developed nano\u2010fibrous poly(<jats:sc>L<\/jats:sc>\u2010lactic acid) scaffolds under the hypothesis that synthetic nano\u2010fibrous scaffolding, mimicking the structure of natural collagen fibers, could create a more favorable microenvironment for cells. This is the first report that the nano\u2010fibrous architecture built in three\u2010dimensional scaffolds improved the features of protein adsorption, which mediates cell interactions with scaffolds. Scaffolds with nano\u2010fibrous pore walls adsorbed four times more serum proteins than scaffolds with solid pore walls. More interestingly, the nano\u2010fibrous architecture selectively enhanced protein adsorption including fibronectin and vitronectin, even though both scaffolds were made from the same poly(<jats:sc>L<\/jats:sc>\u2010lactic acid) material. Furthermore, nano\u2010fibrous scaffolds also allowed &gt;1.7 times of osteoblastic cell attachment than scaffolds with solid pore walls. These results demonstrate that the biomimetic nano\u2010fibrous architecture serves as superior scaffolding for tissue engineering. \u00a9 2003 Wiley Periodicals, Inc. 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