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The cells were analyzed for the production and deposition of pericellular glycoproteins by immunofluorescence and by radioactive metabolic and cell surface labeling techniques followed by analysis in polyacrylamide gels and fluorography. The pericellular fibronectin matrix was lost, but unlike in virus\u2010transformed fibroblastic cells, the production of fibronectin was not affected. The major differences detected were decrease in collagen production and initiation of synthesis of two major glycoproteins with M<jats:sub>r<\/jats:sub> 58,000 and 60,000. Cell surface carbohydrate labeling indicated that after 3611\u2010MSV transformation the cells expressed M<jats:sub>r<\/jats:sub> 100,000 and 68,000 polypeptides. The present and previous results show that viral transformation of epithelial cells induces different transformed phenotypes that are associated with distinct alterations in pericellular glycoproteins.<\/jats:p>","DOI":"10.1002\/jcb.240200206","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T08:33:51Z","timestamp":1104482031000},"page":"139-148","source":"Crossref","is-referenced-by-count":13,"title":["Transformation of MMC\u2010E epithelial cells by acute 3611\u2010MSV: inhibition of collagen synthesis and induction of novel polypeptides"],"prefix":"10.1002","volume":"20","author":[{"given":"Jorma","family":"Keski\u2010Oja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf 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