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Calcium exerted its influence during the induction phase of the process before DNA synthesis began since its removal after the response had fully developed did not alter subsequent levels of nucleic acid synthesis. The early development of RNA synthesis was prevented by low calcium levels indicating that calcium either directly influenced the initiation of this process or some prior event(s).<\/jats:p>","DOI":"10.1002\/jcp.1040800303","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T18:06:44Z","timestamp":1109441204000},"page":"329-337","source":"Crossref","is-referenced-by-count":121,"title":["Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin"],"prefix":"10.1002","volume":"80","author":[{"given":"Richard B.","family":"Whitney","sequence":"first","affiliation":[]},{"given":"Robert M.","family":"Sutherland","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4049\/jimmunol.104.3.698","article-title":"Metal cation requirements for phytohemagglutinin\u2010induced transformation of human peripheral blood lymphocytes","volume":"104","author":"Alford R. 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