{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:19:57Z","timestamp":1759011597308},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,24]],"date-time":"2008-02-24T00:00:00Z","timestamp":1203811200000},"content-version":"vor","delay-in-days":9915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three hundred thirty\u2010six medical personnel from hemodialysis centers were treated with three doses, 20 \u03bcg each, of the Merck hepatitis B vaccine (at 0, 1, and 6 months). Within 1 month after the first injection, 41% converted to anti\u2010HBs positivity; after the second injection the conversion rate rose to 80\u201390%; and after the booster, to 96\u201398%. The later rate remained unchanged during the 18\u2010month follow\u2010up period. Only 2.8% of those vaccinated did not respond to the vaccine. The patterns of immune responses to 20\u2010\u03bcg doses were found to be exactly the same as to 40\u2010\u03bcg doses. It is suggested that reduced doses of vaccine should be as efficacious as the larger ones.<\/jats:p>","DOI":"10.1002\/jmv.1890080206","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T02:20:36Z","timestamp":1172802036000},"page":"123-129","source":"Crossref","is-referenced-by-count":57,"title":["The immune response of healthy adults to a reduced dose of hepatitis B vaccine"],"prefix":"10.1002","volume":"8","author":[{"given":"Wolf","family":"Szmuness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cladd E.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Harley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith A.","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey J.","family":"Alter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"The Dialysis Vaccine Trial Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,24]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Viral Hepatitis","author":"Hilleman RM","year":"1982"},{"key":"e_1_2_1_3_1","volume-title":"Viral Hepatitis","author":"Hollinger FB","year":"1982"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890080205"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-4-489"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890040411"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198010093031501"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010502"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890080206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890080206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:33:57Z","timestamp":1699839237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890080206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jmv.1890080206"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890080206","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}