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The guanine nucleotides, guanosine\u20105\u2032\u2010triphosphate and guanylyl\u20105\u2032\u2010imidodiphosphate, significantly inhibited the binding of radiolabeled vasoactive intestinal polypeptide but not that of [Tyr<jats:sup>4<\/jats:sup>]bombesin to rat brain membranes. Vasoactive intestinal polypeptide binding was inhibited by guanine nucleotides in a dose\u2010dependent manner. Using a 20 \u03bcM dose, 60% of the specific vasoactive intestinal polypeptide binding was inhibited by guanylyl\u20105\u2032\u2010imidodiphosphate, which was more potent than guanosine\u20105\u2032\u2010triphosphate, whereas other nucleotides were not effective. This reduction in binding was a consequence of lower affinity of the receptor for vasoactive intestinal polypeptide, which in turn resulted from an increased rate of dissociation.<\/jats:p>","DOI":"10.1002\/jsscb.1981.380150206","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T13:11:32Z","timestamp":1117285892000},"page":"153-159","source":"Crossref","is-referenced-by-count":12,"title":["Effects of guanine nucleotides on cns neuropeptide receptors"],"prefix":"10.1002","volume":"15","author":[{"given":"Terry W.","family":"Moody","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan P.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace B.","family":"Pert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.12.6139"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33248-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.41.030179.000415"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.11.5372"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.2.660"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80645-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(78)90079-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90281-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62388-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34820-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33257-X"},{"key":"e_1_2_1_13_2","first-page":"335","volume":"12","author":"Maguire ME","year":"1976","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(78)90156-5"},{"key":"e_1_2_1_15_2","first-page":"437","volume":"116","author":"Berrie CP","year":"1979","journal-title":"Brain Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.4.1713"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(72)90866-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62390-7"},{"key":"e_1_2_1_19_2","first-page":"105","volume":"5","author":"Schramm M","year":"1975","journal-title":"Adv Cyclic Nucleotide Res"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90492-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1976.tb02640.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/284017a0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)66956-5"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40089-5"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12585.x"}],"container-title":["Journal of Supramolecular Structure and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsscb.1981.380150206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsscb.1981.380150206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:14:37Z","timestamp":1698858877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jsscb.1981.380150206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jsscb.1981.380150206"],"URL":"https:\/\/doi.org\/10.1002\/jsscb.1981.380150206","archive":["Portico"],"relation":{},"ISSN":["0275-3723","1547-1748"],"issn-type":[{"value":"0275-3723","type":"print"},{"value":"1547-1748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}