{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:52Z","timestamp":1760188852965},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":10426,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with malignancies resistant to conventional therapy were treated with cis\u2010diamminedichloroplatinum (PDD), 1 5 to 20 mg\/m<jats:sup>2<\/jats:sup>, given daily by rapid intravenous infusion for 5 days at 3\u2010wk intervals. Eleven of 24 children with acute lymphocytic leukemia (ALL) received two or more courses; among these no remissions occurred. Fifty\u2010four children with solid tumors were treated: 25 neuroblastoma, 9 rhabdomyosarcoma, 4 Ewing sarcoma, 2 testicular embryonal carcinoma, 2 retinoblastoma, and 12 miscellaneous tumors. One complete remission, 3 partial remissions, and 2 improvements were observed in children with neuroblastoma. One girl with metastatic osteogenic sarcoma achieved a partial remission. One child with metastatic testicular embryonal carcinoma showed improvement. The side effects were vomiting controlled by antiemetics in 26 children and transient elevations of serum creatinine and BUN in 14 children. Nineteen of 39 children with solid tumors, who received more than one course of PDD, had moderately severe myelosuppression caused by PDD. In summary, PDD is a promising agent in neuroblastoma, osteogenic sarcoma, and testicular embryonal carcinoma, and an ineffective agent in ALL. The effect of PDD on other types of solid tumors should be evaluated in the future.<\/jats:p>","DOI":"10.1002\/mpo.2950040208","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:00:25Z","timestamp":1171983625000},"page":"127-132","source":"Crossref","is-referenced-by-count":48,"title":["Cis\u2010diamminedichloroplatinum (NSC\u2010119875) in childhood malignancies: A southwest oncology group study"],"prefix":"10.1002","volume":"4","author":[{"given":"Ruprecht","family":"Nitschke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Starling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tribhawan","family":"Vats","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/235282a0"},{"key":"e_1_2_1_3_2","first-page":"665","article-title":"Action of Cis\u2010dichlorodiammineplatinum (II) (NSC\u2010119875) at the cellular level","volume":"59","author":"Drewinko B","year":"1975","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_4_2","first-page":"621","article-title":"Review of the current clinical status of platinum coordination complexes in cancer chemotherapy","volume":"59","author":"Gottlieb JA","year":"1975","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_5_2","first-page":"465","article-title":"Clinical evaluation of toxic effects of Cis\u2010diamminedichloroplatinum (NSC\u2010119875) \u2013 phase I clinical study","volume":"57","author":"Talley RW","year":"1973","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197405)33:5<1219::AID-CNCR2820330505>3.0.CO;2-U"},{"key":"e_1_2_1_7_2","first-page":"1310","article-title":"Clinical and pharmacological studies with cis\u2010Diamminedichloroplatinum (II)","volume":"33","author":"DeConti RC","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","first-page":"287","article-title":"Chemotherapy of ovarian cancer with adriamycin (ADM) and cis\u2010platinum (DDP) (Abstract)","volume":"17","author":"Bruckner HW","year":"1976","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_9_2","first-page":"243","article-title":"A new method to prevent toxicity with high doses of Cis\u2010Diammine Platinum (therapeutic efficacy in previously treated widespread and recurrent testicular tumors) (Abstract)","volume":"17","author":"Merrin C","year":"1976","journal-title":"Proc Am Soc Clin Oncol"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950040208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950040208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:19:15Z","timestamp":1699827555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950040208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1002\/mpo.2950040208"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950040208","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}