{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:08:57Z","timestamp":1776056937961,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2782,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the pulsed arterial spin labeling (ASL) techniques EPISTAR, PICORE, and FAIR, subtraction of two images in which inflowing blood is first tagged and then not tagged yields a qualitative map of perfusion. An important reason this map is not quantitative is that there is a spatially varying delay in the transit of blood from the tagging region to the imaging slice that cannot be measured from a single subtraction. We introduce here two modifications of pulsed ASL (QUIPSS and QUIPSS II) that avoid this problem by applying additional saturation pulses to control the time duration of the tagged bolus, rendering the technique relatively insensitive to transit delays and improving the quantitation of perfusion.<\/jats:p>","DOI":"10.1002\/mrm.1910390506","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T20:18:16Z","timestamp":1173817096000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":619,"title":["Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II)"],"prefix":"10.1002","volume":"39","author":[{"given":"Eric C.","family":"Wong","sequence":"first","affiliation":[]},{"given":"Richard B.","family":"Buxton","sequence":"additional","affiliation":[]},{"given":"Lawrence R.","family":"Frank","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910250220"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.13.5951"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5675"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.212"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230106"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.2.8029425"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"E. C.Wong L. R.Frank R. B.Buxton Quantitative multislice perfusion imaging using QUIPSS II EPISTAR FAIR and PICORE in \u201cProc. ISMRM 5th Annual Meeting Vancouver 1997 \u201d p.85.","DOI":"10.1016\/S1053-8119(96)80007-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199706\/08)10:4\/5<237::AID-NBM475>3.0.CO;2-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340303"},{"key":"e_1_2_1_11_2","unstructured":"E. C.Wong L. R.Frank R. B.Buxton QUIPSS II: a method for improved quantitation of perfusion using pulsed arterial spin labeling in \u201cProc. ISMRM 5th Annual Meeting Vancouver 1997 \u201d p.1761."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199611000-00019"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199604)9:2<79::AID-NBM399>3.0.CO;2-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340613"},{"key":"e_1_2_1_15_2","article-title":"Quantitative imaging of perfusion using a single subtraction (QUIPSS)","volume":"5","author":"Wong E. C.","year":"1966","journal-title":"Neuroimage"},{"key":"e_1_2_1_16_2","unstructured":"R. B.Buxton E. C.Wong L. R.Frank Quantitation issues in perfusion measurement with dynamic arterial spin labeling in \u201cProc. ISMRM 4th Annual Meeting New York 1996 \u201d p.10."},{"key":"e_1_2_1_17_2","unstructured":"R. B.Buxton L. R.Frank B.Siewert S.Warach R. R.Edelman A quantitative model for EPISTAR perfusion imaging in \u201cProc. SMR 3rd Annual Meeting Nice 1995 \u201d p.132."},{"key":"e_1_2_1_18_2","unstructured":"R. B.Buxton L. R.Frank E. C.Wong B.Siewert S.Warach R. R.Edelman A general kinetic model for quantitative perfusion imaging with arterial spin labeling. Magn. Reson. Med. in press."},{"key":"e_1_2_1_19_2","unstructured":"E. C.Wong R. B.Buxton L. R.Frank Quantitative perfusion imaging using EPISTAR and FAIR in \u201cProc. ISMRM 4th Annual Meeting New York 1996 \u201d p.13."},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370215"},{"key":"e_1_2_1_21_2","unstructured":"E. C.Wong P. A.Bandettini J. S.Hyde Echo\u2010planar imaging of the human brain using a three axis local gradient coil \u201cProc. SMRM 11th Annual Meeting Berlin 1992 \u201d p.105."},{"key":"e_1_2_1_22_2","unstructured":"E. C.Wong E.Boskamp J. S.Hyde A volume optimized quadrature elliptical endcap birdcage brain coil in \u201cProc. SMRM 11th Annual Meeting Berlin 1992 \u201d p.4015."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910210107"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.31.2753"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910380409"},{"key":"e_1_2_1_26_2","unstructured":"R. B.Buxton E. C.Wong L. R.Frank A comparison of perfusion and BOLD changes during brain activation in \u201cProc. ISMRM 5th Annual Meeting Vancouver 1997 \u201d p.153."},{"key":"e_1_2_1_27_2","unstructured":"P. A.Bandettini E. C.Wong Analysis of embedded contrast fMRI: interleaved perfusion BOLD and velocity nulling in \u201cProc. ISMRM 5th Annual Meeting Vancouver 1997 \u201d p.156."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370321"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ima.1850060206"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1910390506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1910390506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T18:32:34Z","timestamp":1698517954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1910390506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1002\/mrm.1910390506"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1910390506","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"1997-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}