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Among them the <jats:italic>rvs161<\/jats:italic> mutant (RVS for <jats:styled-content>R<\/jats:styled-content>educed <jats:styled-content>V<\/jats:styled-content>iability upon <jats:styled-content>S<\/jats:styled-content>tarvation) is sensitive to carbon, nitrogen and sulphur starvation. When these nutrients are depleted in the medium, mutant cells show cellular viability loss with morphological changes. The mutation <jats:italic>rvs161<\/jats:italic>\u2010<jats:italic>1<\/jats:italic> is very pleiotropic, and besides the defects in stationary phase entry, the mutant strain presents other alterations: sensitivity to high salt concentrations, hypersensitivity to amino acid analogs, no growth on lactate or acetate medium. The addition of salts or amino acid analogs leads to the same morphological defects observed in starved cells, suggesting that the gene could be implicated mainly in the control of cellular viability. The gene <jats:italic>RVS161<\/jats:italic> was cloned; it codes for a 30,252 daltons protein. No homology was detected with the proteins contained in the databases. Moreover, Southern analysis revealed the presence of other sequences homologous to the <jats:italic>RVS161<\/jats:italic> gene in the yeast genome.<\/jats:p>","DOI":"10.1002\/yea.320070708","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T23:32:38Z","timestamp":1117323158000},"page":"727-743","source":"Crossref","is-referenced-by-count":102,"title":["Yeast mutant affected for viability upon nutrient starvation: Characterization and cloning of the <i>RVS161<\/i> gene"],"prefix":"10.1002","volume":"7","author":[{"given":"Marc","family":"Crouzet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Urdaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Dulau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Aigle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8516"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81068-2"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/7.6.1513"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(91)90013-J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03981.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(79)90012-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90076-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90572-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04222.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.15.5060"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(87)90261-7"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.4.2173"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327216"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00434078"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)60950-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90173-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(78)90297-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4120.46"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.4.1929"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(87)90131-4"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.4.1185"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.153.1.163-168.1983"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90154-9"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.137.1.1-5.1979"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(83)90039-2"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4049\/jimmunol.126.4.1249","article-title":"In vitro regeneration of resting lymphocytes from stimulated lymphocytes and its inhibition by insulin","volume":"126","author":"Kumogai J.","year":"1981","journal-title":"J. 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