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Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti\u2010cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inhibition of CD147, the chaperone of lactate transporters (MCTs), decreases lactate export in lung cancer cells and sensitizes them to phenformin, leading to a drastic decrease in cell growth. In this study, the development of anti\u2010CD147 targeted liposomes (LUVs) carrying phenformin is envisioned, and their efficacy is evaluated to eliminate lung cancer cells. Herein, the therapeutic effect of free phenformin and anti\u2010CD147 antibody, as well as the efficacy of anti\u2010CD147 LUVs carrying phenformin on A549, H292, and PC\u20109 cell growth, metabolism, and invasion, are evaluated. Data reveals that phenformin decreases 2D and 3D\u2010cancer cell growth and that the anti\u2010CD147 antibody reduces cell invasion. Importantly, anti\u2010CD147 LUVs carrying phenformin are internalized by cancer cells and impaired lung cancer cell growth in vitro and in vivo. Overall, these results provide evidence for the effectiveness of anti\u2010CD147 LUVs carrying phenformin in compromising lung cancer cell aggressiveness.<\/jats:p>","DOI":"10.1002\/adbi.202300080","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T01:32:43Z","timestamp":1686533563000},"source":"Crossref","is-referenced-by-count":9,"title":["Combination Therapy With CD147\u2010Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth"],"prefix":"10.1002","volume":"7","author":[{"given":"Andreia","family":"Pereira\u2010Nunes","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho  Campus de Gualtar 4710\u2010057 Braga Portugal"},{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"}]},{"given":"Helena","family":"Ferreira","sequence":"additional","affiliation":[{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"},{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco 4805\u2010017 Guimar\u00e3es Portugal"}]},{"given":"Sara","family":"Abreu","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho  Campus de Gualtar 4710\u2010057 Braga Portugal"},{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"}]},{"given":"Marta","family":"Guedes","sequence":"additional","affiliation":[{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"},{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco 4805\u2010017 Guimar\u00e3es Portugal"}]},{"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"},{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco 4805\u2010017 Guimar\u00e3es Portugal"}]},{"given":"F\u00e1tima","family":"Baltazar","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho  Campus de Gualtar 4710\u2010057 Braga Portugal"},{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-6751","authenticated-orcid":false,"given":"Sara","family":"Granja","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho  Campus de Gualtar 4710\u2010057 Braga Portugal"},{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory  Guimar\u00e3es 4710\u2010057 Braga Portugal"},{"name":"Department of Pathological Cytological and Thanatological Anatomy ESS|P.PORTO  4200\u2010072 Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2023,6,11]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00312-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0731-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-8-102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S146315"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9348-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557513666131119202717"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017411"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111803"},{"key":"e_1_2_10_10_1","first-page":"252","volume":"24","author":"Kuang Y. 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