{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:51:59Z","timestamp":1759452719440,"version":"build-2065373602"},"reference-count":116,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/94277\/2013 - CTTI-58\/18-I3Bs(4)","PD\/BD\/143044\/2018","PTDC\/BTMMAT\/29760\/2017 (POCI-01-0145-FEDER-029760)"],"award-info":[{"award-number":["SFRH\/BPD\/94277\/2013 - CTTI-58\/18-I3Bs(4)","PD\/BD\/143044\/2018","PTDC\/BTMMAT\/29760\/2017 (POCI-01-0145-FEDER-029760)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Eng Mater"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Osteoarthritis (OA) is a progressive degenerative disease that causes severe pain and functional limitation, especially during locomotion. It is the most common arthritis type that damages the surface of articular cartilage until the underlying bone. In the past decade, the scientific community has made a considerable effort to improve or discover therapeutical products used as a form of conservative treatment capable of restoring the damaged articular tissue, avoiding, as far as possible, the use of surgical practices. The most common and direct nonoperative application available for OA treatment is the viscosupplementation (VS) procedure that demonstrates a safe, effective method and is less painful for the patients. The most recent works dealing with the design, development, and validation of viscosupplement products in preclinical and clinical trials for OA treatment are overviewed herein. In general, despite the development of new products, hyaluronic acid continues to be among the most reported intra\u2010articular viscosupplement products used in clinical trials, typically used as an isolated product or conjugated with other biologicals or drugs, such as platelet\u2010rich plasma and corticosteroids (CS). However, this issue is still demanding innovation. Approaches comprising new biomaterials as VS products, with intrinsic bioactivity, economical, and environmental friendliness, are required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/adem.202101541","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T08:09:41Z","timestamp":1647418181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review"],"prefix":"10.1002","volume":"24","author":[{"given":"Cristiana","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra 4805-017 Guimar\u00e3es Barco Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory  Guimar\u00e3es Barco Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-0012","authenticated-orcid":false,"given":"Duarte Nuno","family":"Carvalho","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra 4805-017 Guimar\u00e3es Barco Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory  Guimar\u00e3es Barco Portugal"}]},{"given":"Tiago H.","family":"Silva","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra 4805-017 Guimar\u00e3es Barco Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory  Guimar\u00e3es Barco Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-6129","authenticated-orcid":false,"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra 4805-017 Guimar\u00e3es Barco Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory  Guimar\u00e3es Barco Portugal"}]},{"given":"J. Miguel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs \u2013 Research Institute on Biomaterials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho  AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra 4805-017 Guimar\u00e3es Barco Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory  Guimar\u00e3es Barco Portugal"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415853-5.00019-4"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-08495-6.00006-3"},{"key":"e_1_2_7_3_1","first-page":"34","volume-title":"Stevens & Lowe's Human Histology E-Book","author":"Lowe J. S.","year":"2014"},{"key":"e_1_2_7_4_1","unstructured":"B. B.David R.Matthew Vol.1 Elsevier Inc 2014 1 pp.34\u201341."},{"key":"e_1_2_7_5_1","unstructured":"M.Dennis Clinical imaging with skeletal chest and abdomen pattern differentials Mosby Elsevier 2005 pp.1\u20131468."},{"key":"e_1_2_7_6_1","unstructured":"a)L.Gower (Eds.:C.Aparicio MPGinebra) Biomineralization and biomaterials: fundamentals and applications Cambridge United Kingdom: Woodhead 2016;"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385189-5.00013-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.035"},{"volume-title":"High Yield Orthopaedics E-Book","year":"2010","author":"Parvizi J.","key":"e_1_2_7_8_1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2014.04.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.10.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.05.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-78242-452-9.00010-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811837-5.00003-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781782623663-00001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","unstructured":"R. S.Decker presented atSeminars in Cell & Developmental Biology Elsevier2017 62 pp.50\u201356.","DOI":"10.1016\/j.semcdb.2016.10.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.95"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2012.01.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","unstructured":"M.Cutolo F.Berenbaum M.Hochberg L.Punzi J.-Y.Reginster presented atSeminars in Arthritis and Rheumatism 2015 44 pp.611\u2013617https:\/\/doi.org\/10.1016\/j.semarthrit.2014.12.003.","DOI":"10.1016\/j.semarthrit.2014.12.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100587"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.03.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24021"},{"key":"e_1_2_7_22_1","first-page":"197","volume":"35","author":"Hiligsmann M.","year":"2013","journal-title":"Medicographia"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.03.012"},{"key":"e_1_2_7_24_1","first-page":"31","volume":"12","author":"Migliore A.","year":"2015","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.1.000037"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.09.040"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.23.3115"},{"key":"e_1_2_7_28_1","unstructured":"T.J\u00f6nsson Lund University 2020."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/454873"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030658"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.3.170060"},{"volume-title":"StatPearls","year":"2021","author":"Varacallo M.","key":"e_1_2_7_33_1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-019-0177-5"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-38962-4.00102-8"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-015-9299-2"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.08.002"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00192"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147868"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2018.04.003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812364-5.00003-1"},{"key":"e_1_2_7_42_1","unstructured":"K. A.Vikram K. S.Narayana G. P.Kumar C.Skandha International Journal on Theoretical and Applied Research in Mechanical Engineering 2014 3 33."},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","unstructured":"A.Rafidah A.Nurulhuda A.Azrina Y.Suhaila I.Anwar R.Syafiq presented atApplied Mechanics and Materials 2014 660 pp.275\u2013279https:\/\/doi.org\/10.4028\/www.scientific.net\/AMM.660.275.","DOI":"10.4028\/www.scientific.net\/AMM.660.275"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030658"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0688-y"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","unstructured":"E.Maheu F.Rannou J.-Y.Reginster presented atSeminars in Arthritis and Rheumatism 2016 45 pp.28\u201333.","DOI":"10.1016\/j.semarthrit.2015.11.008"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbo.2017.04.014"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00469"},{"key":"e_1_2_7_49_1","doi-asserted-by":"crossref","unstructured":"P.Vincent Current Therapeutic Research Clinical and Experimental 2019 90 pp.39\u201351.","DOI":"10.1016\/j.curtheres.2019.02.003"},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","unstructured":"V. K. L.Suppan C. Y.Wei T. C.Siong T. M.Mei W. B.Chern V. K.Nanta Kumar K. R.Sheng A.Sadashiva Rao Journal of Orthopaedic Surgery2017 25 1.","DOI":"10.1177\/2309499017731627"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","unstructured":"M.Ricci G.Micheloni M.Berti F.Perusi E.Sambugaro E.Vecchini B.Magnan Musculoskelet Surgical 2017 101 45.","DOI":"10.1007\/s12306-016-0428-x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1603677"},{"key":"e_1_2_7_53_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2147\/OARRR.S245766","volume":"12","author":"Khangulov V.","year":"2020","journal-title":"J. Open Access Rheumatol.: Res. Rev."},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-020-00127-7"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.5792\/ksrr.16.061"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1260533"},{"key":"e_1_2_7_57_1","doi-asserted-by":"crossref","unstructured":"C. C.Lopes de Jesus F. C.Dos Santos L. M. O. B.de Jesus I.Monteiro M. S. S. C.Sant'Ana V. F. M. J. P. o.Trevisani double\u2010blinded placebo\u2010controlled study PLoS One 2017 12 e0179185.","DOI":"10.1371\/journal.pone.0179185"},{"key":"e_1_2_7_58_1","first-page":"621","volume":"30","author":"Giombini A.","year":"2016","journal-title":"J. Biol. Regul. Homeostatic Agents"},{"key":"e_1_2_7_59_1","first-page":"621","volume":"30","author":"Giombini A.","year":"2016","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1352-1"},{"key":"e_1_2_7_61_1","doi-asserted-by":"crossref","unstructured":"E.Mariani V.Canella L.Cattini E.Kon M.Marcacci B.Di Matteo L.Pulsatelli G.Filardo PLoS One 2016 11 e0156137.","DOI":"10.1371\/journal.pone.0156137"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S123900"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.07.027"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/1457496918812218"},{"key":"e_1_2_7_65_1","first-page":"21","volume":"33","author":"Papalia R.","year":"2019","journal-title":"J. Biol. Reg. Homeostatic Agents"},{"key":"e_1_2_7_66_1","first-page":"17","volume":"30","author":"Papalia R.","year":"2016","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157048"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00132-018-03659-5"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2019.100573"},{"key":"e_1_2_7_70_1","first-page":"75","volume":"19","author":"Pavelka K.","year":"2021","journal-title":"J. Clin. Orthopaedics"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.15584\/ejcem.2021.1.4"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2016.05.015"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMAMD.S39432"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1361-8"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0856-z"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.01.017"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23191"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2019\/e1207"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519847737"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0012.8277"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1783234"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518814532"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aott.2016.07.008"},{"key":"e_1_2_7_84_1","first-page":"26","volume":"20","author":"Gigis I.","year":"2016","journal-title":"Hippokratia"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00100"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-019-1030-2"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13534-017-0010-y"},{"key":"e_1_2_7_88_1","first-page":"543","volume":"27","author":"Saggini R.","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116787"},{"key":"e_1_2_7_90_1","first-page":"681","volume":"68","author":"Consumi M.","year":"2020","journal-title":"Int. J. Polymeric Mater. Polymeric Biomater."},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4047628"},{"key":"e_1_2_7_92_1","first-page":"194760352096707","volume":"1","author":"Langworthy M. J.","year":"2020","journal-title":"Cartilage"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04475"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00085"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.009"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-08340-9.00071-2"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.06.002"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00192"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.08.005"},{"key":"e_1_2_7_99_2","unstructured":"b)K.Tran L. H. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health 2019."},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-013-0068-6"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2018.10.003"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-016-0428-x"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518768015"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516654909"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-017-2083-9"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00469"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10030"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-874"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179544118782901"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.07.073"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2016.05.015"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1585-2"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2019\/e1207"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-017-3625-9"}],"container-title":["Advanced Engineering Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adem.202101541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adem.202101541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adem.202101541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:25:50Z","timestamp":1759425950000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adem.202101541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,16]]},"references-count":116,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/adem.202101541"],"URL":"https:\/\/doi.org\/10.1002\/adem.202101541","archive":["Portico"],"relation":{},"ISSN":["1438-1656","1527-2648"],"issn-type":[{"type":"print","value":"1438-1656"},{"type":"electronic","value":"1527-2648"}],"subject":[],"published":{"date-parts":[[2022,3,16]]},"assertion":[{"value":"2021-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2101541"}}