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Here, spermine\u2010modified acetalated dextran nanoparticles (Sp\u2010AcDEX NPs), co\u2010loaded with the non\u2010genotoxic molecule Nutlin\u20103a (Nut3a), and the cytokine granulocyte\u2013macrophage colony\u2010stimulating factor (GM\u2010CSF), are developed to induce cancer cell death and create a specific antitumor immune response. These polymeric NPs release Nut3a in a pH dependent fashion and induce endosomal escape. Due to Nut3a, the loaded NPs exert specific toxicity toward wild\u2010type p53 cancer cells while avoiding toxicity in immune cells. Furthermore, the NPs show intrinsic immune adjuvancy on monocyte derived\u2010dendritic cells, upregulating the expression of cell surface CD83 and CD86 costimulatory markers. Finally, it is examined that by inducing MCF\u20107 breast cancer cell death and acting as immune adjuvants, the NPs can downregulate the expression of IL\u201010 and upregulate IL\u20101\u03b2, leading to proliferation of CD3<jats:sup>+<\/jats:sup> and cytotoxic CD8<jats:sup>+<\/jats:sup> T cells. Overall, the study suggests that Sp\u2010AcDEX NPs loaded with Nut3a and GM\u2010CSF is a promising system for chemo\u2010immunotherapy, capable of inducing tumor cell death and stimulating immune response.<\/jats:p>","DOI":"10.1002\/adfm.201703303","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T08:26:48Z","timestamp":1504513608000},"source":"Crossref","is-referenced-by-count":77,"title":["Nutlin\u20103a and Cytokine Co\u2010loaded Spermine\u2010Modified Acetalated Dextran Nanoparticles for Cancer Chemo\u2010Immunotherapy"],"prefix":"10.1002","volume":"27","author":[{"given":"Tom\u00e1s","family":"Bauleth\u2010Ramos","sequence":"first","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  FI\u201000014 Helsinki Finland"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S) University of Porto  Rua Alfredo Allen, 208 4200\u2010135 Porto Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB) University of Porto  Rua Alfredo Allen, 208 4200\u2010135 Porto Portugal"},{"name":"Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS) University of Porto  Rua Jorge Viterbo 228 4150\u2010180 Porto Portugal"}]},{"given":"Mohammad\u2010Ali","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  FI\u201000014 Helsinki Finland"},{"name":"Department of Micro\u2010 and Nanotechnology Technical University of Denmark  \u00d8rsteds Plads DK\u20102800 Kgs. 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