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Here, a hybrid nanowire (NW) for targeted bioorthogonally driven activation of the latent chemotherapeutic prodrug 5\u2010fluoro\u20101\u2010propargyl\u2010uracil (Pro\u20105\u2010FU) in in vitro and in vivo cancer models is proposed. The NWs are composed of magnetic iron (Fe) and palladium (Pd), a known bioorthogonal catalyst. In vitro tests with a cancer cell line showed no significant cytotoxic effect by the NWs. In contrast, NWs combined with Pro\u20105\u2010FU lead to a significant reduction of cell viability, similarly to the one induced by its active chemotherapeutic counterpart 5\u2010fluorouracil (5\u2010FU). The reduction in cell viability is attributed to the catalytic activation of Pro\u20105\u2010FU into 5\u2010FU. To demonstrate their targeted therapeutic abilities, magnetic fields are used to attract the FePd NWs to a predefined area within a cultured cancer cell population, causing a local Pro\u20105\u2010FU activation, and subsequent cell death in this region. As a proof of concept, NWs are injected in cancer tumor xenografts. The intraperitoneal injection of Pro\u20105\u2010FU significantly retards tumour growth without causing significant side effects. This work presents a novel chemotherapeutic approach combining nanorobotics and bioorthogonal activation of prodrugs as an efficient alternative to conventional chemotherapy.<\/jats:p>","DOI":"10.1002\/adfm.201705920","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T05:29:33Z","timestamp":1515994173000},"source":"Crossref","is-referenced-by-count":126,"title":["Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6482-1295","authenticated-orcid":false,"given":"Marcus","family":"Hoop","sequence":"first","affiliation":[{"name":"Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich  Tannenstrasse 3 CH\u20108092 Zurich Switzerland"}]},{"given":"Ana Sofia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"IPATIMUP \u2013 Institute of Molecular Pathology and Immunology of the University of Porto Rua J\u00falio Amaral de Carvalho, 45  4200\u2010135 Porto Portugal"},{"name":"i3S \u2013 Institute for Investigation and Innovation in Health University of Porto, Portugal Rua Alfredo Allen 208  4200\u2010135 Porto Portugal"}]},{"given":"Daniel","family":"R\u00f6sch","sequence":"additional","affiliation":[{"name":"Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich  Tannenstrasse 3 CH\u20108092 Zurich Switzerland"}]},{"given":"Philipp","family":"Weinand","sequence":"additional","affiliation":[{"name":"Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich  Tannenstrasse 3 CH\u20108092 Zurich Switzerland"}]},{"given":"Nuno","family":"Mendes","sequence":"additional","affiliation":[{"name":"IPATIMUP \u2013 Institute of Molecular Pathology and Immunology of the University of Porto Rua J\u00falio Amaral de Carvalho, 45  4200\u2010135 Porto Portugal"}]},{"given":"Fajer","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich  Tannenstrasse 3 CH\u20108092 Zurich Switzerland"}]},{"given":"Xiang\u2010Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich  Tannenstrasse 3 CH\u20108092 Zurich Switzerland"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Health ETH Zurich  Schmelzbergstrasse 7 CH\u20108092 Zurich Switzerland"}]},{"given":"Carlos Franco","family":"Pujante","sequence":"additional","affiliation":[{"name":"Institute of Chemical and Bioengineering ETH Z\u00fcrich  Vladimir Prelog Weg 1 8093 Zurich Switzerland"}]},{"given":"Josep","family":"Puigmart\u00ed\u2010Luis","sequence":"additional","affiliation":[{"name":"Institute of Chemical and Bioengineering ETH Z\u00fcrich  Vladimir Prelog Weg 1 8093 Zurich Switzerland"}]},{"given":"Joana","family":"Paredes","sequence":"additional","affiliation":[{"name":"IPATIMUP \u2013 Institute of Molecular Pathology and Immunology of the University of Porto Rua J\u00falio Amaral de Carvalho, 45  4200\u2010135 Porto Portugal"},{"name":"i3S \u2013 Institute for Investigation and Innovation in Health University of Porto, Portugal Rua Alfredo Allen 208  4200\u2010135 Porto Portugal"}]},{"given":"Bradley J.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich  Tannenstrasse 3 CH\u20108092 Zurich Switzerland"}]},{"given":"Ana Paula","family":"P\u00eago","sequence":"additional","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica  Rua Alfredo Allen 208 4200\u2010135 Porto Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS) Universidade do Porto  Rua de Jorge Viterbo Ferreira 228 4050\u2010313 Porto Portugal"},{"name":"Faculdade de Engenharia da Universidade do Porto R. 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