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Articular cartilage and intervertebral discs (IVDs) are avascular and aneural tissues with abundant extracellular matrix, low cell density, and reduced regenerative capacity after damage or degeneration. The most advanced in vitro and ex vivo cell\u2010\/tissue\u2010\/biomaterial\u2010based models and technologies to improve physiological mimicry are discussed, focusing on the impact of inflammation on articular repair\/regeneration. In addition, in vivo models, developed to study cartilage and IVD repair\/regeneration are addressed. While animal models continue to provide crucial mechanistic and preclinical data, more advanced and robust in vitro\/ex vivo cartilage and IVD models, with appropriate extracellular matrix cues and allowing for cellular crosstalk, have seen an exponential growth in the last decade. Due to the complexity of articular microenvironments, adequate in vitro\/ex vivo\/in vivo models are essential to study the molecular mechanisms underlying articular diseases and develop new therapies for repair\/regeneration.<\/jats:p>","DOI":"10.1002\/adfm.201909523","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:28:46Z","timestamp":1583479726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Articular Repair\/Regeneration in Healthy and Inflammatory Conditions: From Advanced In Vitro to In Vivo Models"],"prefix":"10.1002","volume":"30","author":[{"given":"Jos\u00e9 H.","family":"Teixeira","sequence":"first","affiliation":[{"name":"I3S \u2010 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade and INEB \u2010 Instituto Nacional de Engenharia Biom\u00e9dica University of Porto  Porto 4200\u2010135 Portugal"},{"name":"ICBAS \u2010 Instituto de 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