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Cell therapy shows promise as a potential treatment for these diseases. However, the therapeutic targeted delivery of these cells and the in situ provision of a suitable microenvironment for their differentiation into functional neuronal networks remain challenging. A highly integrated multifunctional soft helical microswimmer featuring targeted neuronal cell delivery, on\u2010demand localized wireless neuronal electrostimulation, and post\u2010delivery enzymatic degradation is introduced. The helical soft body of the microswimmer is fabricated by two\u2010photon lithography of the photocurable gelatin\u2013methacryloyl (GelMA)\u2010based hydrogel. The helical body is then impregnated with composite multiferroic nanoparticles displaying magnetoelectric features (MENPs). While the soft GelMA hydrogel chassis supports the cell growth, and is degraded by enzymes secreted by cells, the MENPs allow for the magnetic transportation of the bioactive chassis, and act as magnetically mediated electrostimulators of neuron\u2010like cells. The unique combination of the materials makes these microswimmers highly integrated devices that fulfill several requirements for their future translation to clinical applications, such as cargo delivery, cell stimulation, and biodegradability. The authors envision that these devices will inspire new avenues for targeted cell therapies for traumatic injuries and diseases in the central nervous system.<\/jats:p>","DOI":"10.1002\/adfm.201910323","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T01:15:17Z","timestamp":1583111717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":262,"title":["3D\u2010Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron\u2010Like Cells"],"prefix":"10.1002","volume":"30","author":[{"given":"Mei","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Polymer Science and Engineering and Key Laboratory of High Performance Polymer Materials and Technology of MOE School of Chemistry and Chemical Engineering Nanjing University  Nanjing 210023 China"}]},{"given":"Xiaopu","family":"Wang","sequence":"additional","affiliation":[{"name":"Multi\u2010Scale Robotics Lab (MSRL) Institute of Robotics &amp; Intelligent Systems (IRIS) ETH Zurich  Zurich 8092 Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-7487","authenticated-orcid":false,"given":"Xiang\u2010Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Multi\u2010Scale Robotics Lab (MSRL) Institute of Robotics &amp; Intelligent Systems (IRIS) ETH Zurich  Zurich 8092 Switzerland"}]},{"given":"Fajer","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Multi\u2010Scale Robotics Lab (MSRL) Institute of Robotics &amp; Intelligent Systems (IRIS) ETH Zurich  Zurich 8092 Switzerland"}]},{"given":"Siyu","family":"Deng","sequence":"additional","affiliation":[{"name":"Multi\u2010Scale Robotics Lab (MSRL) Institute of Robotics &amp; Intelligent Systems (IRIS) ETH Zurich  Zurich 8092 Switzerland"}]},{"given":"Caihong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology School of Basic Medical Sciences Fudan University  Shanghai China"}]},{"given":"Harun","family":"Torlakcik","sequence":"additional","affiliation":[{"name":"Multi\u2010Scale Robotics Lab (MSRL) Institute of Robotics &amp; Intelligent Systems (IRIS) ETH Zurich  Zurich 8092 Switzerland"}]},{"given":"Anastasia","family":"Terzopoulou","sequence":"additional","affiliation":[{"name":"Multi\u2010Scale Robotics Lab (MSRL) Institute of Robotics &amp; Intelligent Systems (IRIS) ETH Zurich  Zurich 8092 Switzerland"}]},{"given":"Xiao\u2010Hua","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute for Biomechanics ETH Zurich  Leopold\u2010Ruzicka\u2010Weg 4 Zurich 8093 Switzerland"}]},{"given":"Xuanzhong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Polymer Science and Engineering and Key Laboratory of High Performance Polymer Materials and Technology of MOE School of Chemistry and Chemical Engineering Nanjing University  Nanjing 210023 China"}]},{"given":"Josep","family":"Puigmart\u00ed\u2010Luis","sequence":"additional","affiliation":[{"name":"Institute of Chemical and Bioengineering ETH Zurich  Vladimir Prelog Weg 1 8093 Zurich Switzerland"}]},{"given":"Hongsoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Robotics Engineering and DGIST\u2010ETH Microrobot Research Center Daegu Gyeongbuk Institute of Science and Technology (DGIST)  42988 Daegu South Korea"}]},{"given":"Ana Paula","family":"P\u00eago","sequence":"additional","affiliation":[{"name":"INEB \u2013 Instituto de Engenharia Biom\u00e9dica Universidade do Porto (UPorto)  Rua Alfredo Allen 208 4200\u2010135 Porto Portugal"},{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade UPorto  Rua Alfredo Allen 208 4200\u2010135 Porto Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar UPorto  R. 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