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The response to voltage pulses consists of amplitude\u2010depressed current spiking mimicking the short\u2010term plasticity (STP) of synapses. An equivalent circuit hints that the STP timescale of the device arises from the capacitance and resistance of the poly(3,4\u2010ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) in series with the electrolyte resistance. Both the capacitance and resistance of PEDOT:PSS change with solution compositions. Dose curves are constructed from the STP timescale for each DA metabolite from pM to mM range of concentrations. The STP response of DA is distinctive from the other metabolites even when differences are by one functional group. Both STP and sensitivity to DA are larger across the patho\u2010physiological range with respect to those to DA metabolites. Density functional theory calculations hint to a stronger hydrogen bond pattern of DA ammonium compared to cationic metabolites. The exponential correlation between STP and the binding energy of DA metabolites interacting with PEDOT:PSS indicates that the slow dynamics of ionic species in and out PEDOT:PSS is the origin of the neuromorphic STP. The sensing framework discriminates differences of nonspecific interactions of few kcal mol<jats:sup>\u22121<\/jats:sup>, corresponding to one functional group in the molecule.<\/jats:p>","DOI":"10.1002\/adfm.202002141","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T03:05:49Z","timestamp":1590635149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neuromorphic Organic Devices that Specifically Discriminate Dopamine from Its Metabolites by Nonspecific Interactions"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-5788","authenticated-orcid":false,"given":"Martina","family":"Giordani","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche Metaboliche e Neuroscienze Centro di Neuroscienze e Neurotecnologie (CFNN)\u2013Universit\u00e0 di Modena e Reggio Emilia  Via Campi 287 Modena 41125 Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-7161","authenticated-orcid":false,"given":"Matteo","family":"Sensi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita\u2013Universit\u00e0 di Modena e Reggio Emilia  Via Campi 103 Modena 41125 Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-8829","authenticated-orcid":false,"given":"Marcello","family":"Berto","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita\u2013Universit\u00e0 di Modena e Reggio Emilia  Via Campi 103 Modena 41125 Italy"}]},{"given":"Michele","family":"Di Lauro","sequence":"additional","affiliation":[{"name":"Center for Translational Neurophysiology\u2013Istituto Italiano di Tecnologia  Via Fossato di Mortara 17\u201019 Ferrara 44100 Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5701-5727","authenticated-orcid":false,"given":"Carlo Augusto","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita\u2013Universit\u00e0 di Modena e Reggio Emilia  Via Campi 103 Modena 41125 Italy"}]},{"given":"Henrique Leonel","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Telecomunica\u00e7\u00f5es  Avenida Rovisco, Pais 1 Lisboa 1049\u2010001 Portugal"},{"name":"Faculdade de Ci\u00eancias e Tecnologia Universidade do Algarve  Faro 8005\u2010139 Portugal"}]},{"given":"Michele","family":"Zoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche Metaboliche e Neuroscienze Centro di Neuroscienze e Neurotecnologie (CFNN)\u2013Universit\u00e0 di Modena e Reggio Emilia  Via Campi 287 Modena 41125 Italy"}]},{"given":"Francesco","family":"Zerbetto","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica \u201cG. 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