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In this work, the fabrication of layered biomolecular crystals of diphenylalanine (FF) obtained via a co\u2010assembly of <jats:sc>l,l<\/jats:sc>\u2010 and <jats:sc>d,d<\/jats:sc>\u2010 enantiomers of FF monomers is reported. Their crystal structure, thermal and chemical stabilities, and piezoelectric properties are investigated. Single crystal X\u2010ray diffraction results show that FF enantiomers are arranged in the form of bilayers consisting of monomers with alternating chirality packed into a tape\u2010like monoclinic structure belonging to a polar space group <jats:italic>P<\/jats:italic>2<jats:sub>1<\/jats:sub>. Each bilayer (<jats:bold>\u2248<\/jats:bold>1.5\u00a0nm thick) demonstrates strong out\u2010of\u2010plane piezoelectricity (<jats:italic>d<\/jats:italic><jats:sub>33<\/jats:sub>\u00a0<jats:bold>\u2248<\/jats:bold>\u00a020\u00a0pm V<jats:sup>\u22121<\/jats:sup>) that is almost an order of magnitude higher than in the archetypical piezoelectric material quartz. The\u00a0grown crystals demonstrate better thermal and chemical stabilities than self\u2010assembled hexagonal FF nanotubes studied in the past. Piezoelectric bilayers, being held via weak aromatic interaction in the bulk crystals, can be exfoliated by mechanical or chemical methods, thus resulting in a 2D piezoelectric material, which can find various applications in biocompatible and ecologically friendly electromechanical microdevices, such as sensors, actuators, and energy harvesting elements used in implantable and wearable electronics.<\/jats:p>","DOI":"10.1002\/adfm.202102524","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T10:28:15Z","timestamp":1625308095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["2D Layered Dipeptide Crystals for Piezoelectric Applications"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-4785","authenticated-orcid":false,"given":"Pavel S.","family":"Zelenovskii","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; 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