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Among other subcellular organelles, mitochondria generate ATP as intracellular powerhouse, and are associated with multiple aspects of tumorigenesis and tumor development. Here, a mitochondrial anchored biomimetic nanoplatform (CZACN) is designed and its reversal of tumor hypoxia microenvironment underlying the mitochondria\u2010located chemo\u2010photothermal therapy is studied. After shuttling into cancer cells, therapeutic payloads including cisplatin (CDDP) and Au nanozymes are controllably released in the ATP\u2010overexpressed mitochondria. CDDP generates O<jats:sub>2<\/jats:sub>\u2022<jats:sup>\u2212<\/jats:sup>, forms H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> for a chemical fuel in the next reaction, and damages mitochondrial DNA. Meanwhile, the catalase\u2010like Au nanozymes catalyze the produced hydrogen peroxide for oxygen supply to relieve hypoxic tumor microenvironment, offering cytotoxic singlet oxygen against cancer cells under NIR treatment. As a result of cancer\u2010cell self\u2010recognition, mitochondria\u2010targeted therapy, and photothermal conversion ability, the fabricated CZACNs obtained 89.2 \u00b1 3.70%\u00a0of tumor growth inhibition under NIR irradiation and constrained the dose\u2010limiting toxicity of CDDP, as well. These findings reinforce the synergistic effect of organelle\u2010specific navigation and in situ oxygen self\u2010sufficiency for combinational chemo\u2010photothermal therapy.<\/jats:p>","DOI":"10.1002\/adfm.202108603","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T05:44:36Z","timestamp":1639892676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Organelle\u2010Specific Anchored Delivery System Stretching a Reversal of Tumor Hypoxia Microenvironment to a Combinational Chemo\u2010Photothermal Therapy"],"prefix":"10.1002","volume":"32","author":[{"given":"Xuerui","family":"Chen","sequence":"first","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Medicine &amp; School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}]},{"given":"Xuelian","family":"Yin","sequence":"additional","affiliation":[{"name":"Tumor 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