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Protein nanofibrils, such as lysozyme nanofibrils (LNFs), are biocompatible nanostructures with excellent mechanical performance, water insolubility, and antioxidant activity exploited to fabricate materials for different biomedical applications. In this study, LNFs are used to produce gelatin electrospun nanocomposite cardiac patches with improved properties. The addition of the LNFs to the gelatin electrospun patches enhance their mechanical properties, increasing the patches Young's modulus from 3 to 6\u00a0MPa, in their wet state, which agrees with the requirements of myocardial contractility. Additionally, it is observed an increment of the antioxidant activity to 80%, by adding only 5% (w\/w) of LNFs, and the bioresorbability rate is shortened to 30\u201335 d, compared to 45 d for the gelatin\u2010only patches, while maintaining their morphology, and biocompatibility toward cardiomyoblasts and fibroblasts. Furthermore, 15% of a model drug is burst released from the patches and preserved for 21 d. Overall, these results demonstrate that LNFs have a great potential as functional reinforcements to fabricate biopolymeric electrospun patches for myocardial infarcted tissue regeneration.<\/jats:p>","DOI":"10.1002\/adfm.202113390","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:34:17Z","timestamp":1646008457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Gelatin\u2010Lysozyme Nanofibrils Electrospun Patches with Improved Mechanical, Antioxidant, and Bioresorbability Properties for Myocardial Regeneration Applications"],"prefix":"10.1002","volume":"32","author":[{"given":"Tiago","family":"Carvalho","sequence":"first","affiliation":[{"name":"CICECO\u2013Aveiro Institute of Materials Chemistry Department University of Aveiro  Campus de Santiago Aveiro 3810\u2010193 Portugal"},{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Nazanin Zanjanizadeh","family":"Ezazi","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Carla","family":"Vilela","sequence":"additional","affiliation":[{"name":"CICECO\u2013Aveiro Institute of Materials Chemistry Department University of Aveiro  Campus de Santiago Aveiro 3810\u2010193 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-6309","authenticated-orcid":false,"given":"H\u00e9lder A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"},{"name":"Department of Biomedical Engineering University Medical Center Groningen\/University of Groningen  Ant. 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