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Such a process leads to lactate accumulation in the tumor microenvironment (TME), further promoting cancer progression and inducing immunosuppression. Herein, functionalized dendrimer\u2010Cu(II) complexes (for short, D\u2010Cu(II)) as a nanocarrier, which enables a Fenton\u2010like reaction is developed to generate a large amount of hydroxyl radicals and shows a <jats:italic>T<jats:sub>1<\/jats:sub><\/jats:italic>\u2010weighted magnetic resonance (MR) imaging performance. Importantly, the D\u2010Cu(II) allows efficient delivery of lactate oxidase (LOx) to cancer cells, directly downregulating the lactate levels. When combining with an immune activator of leukadherin\u20101, the developed D\u2010Cu(II)\/LOx complexes alleviate the symptoms of mouse leukemia. 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