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Herein, the design of an oxygen\/heat dual\u2010driven stomatocyte nanomotor is showcased by integrating gold (Au) nanoparticles (NPs) and cerium oxide (CeO<jats:sub>2\u2010x<\/jats:sub>) NPs into artificial stomatocytes (Ce\/Au\u2010Stomatocytes) that are further coated with cancer cell membranes (CM). The prepared Ce\/Au\u2010Stomatocytes with anisotropic morphology possess multiple enzyme\u2010mimetic activities and desired oxygen\/heat dual\u2010driven motion performances upon laser irradiation, and can actively accumulate at the tumor site through CM\u2010mediated homotypic targeting. Importantly, the CeO<jats:sub>2\u2010x<\/jats:sub> NPs inside stomatocytes enable oxygen production in the tumor microenvironment, thus relieving hypoxia and helping the stomatocytes deeply enter the tumor region via oxygen\u2010induced motion. Upon laser irradiation of the tumor region, the surface\u2010coated Au NPs can be activated to generate heat to induce thermophoretic motion for highly efficient photothermal therapy (PTT) via motion\u2010enhanced tumor penetration. More importantly, the CeO<jats:sub>2\u2010x<\/jats:sub> NPs can alleviate the abnormal inflammatory responses triggered by PTT, thereby reducing skin damage after laser irradiation. Overall, this study provides a new approach to developing bionic, functional, and oxygen\/heat dual\u2010driven nanomotors with promising performance for enhanced antitumor PTT without the generation of a non\u2010desired inflammation effect.<\/jats:p>","DOI":"10.1002\/adfm.202500113","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:10:33Z","timestamp":1741713033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Oxygen and Heat Dual\u2010Driven Stomatocyte Nanomotors for Highly Efficient Inflammation\u2010Relieved Breast Tumor Photothermal Therapy"],"prefix":"10.1002","volume":"35","author":[{"given":"Yunqi","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 P. 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