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Herein, we develop exosome (Exo)\u2010coated pH\u2010sensitive dendrimer nanogels (DNGs) as a potent therapeutic cancer nanovaccine through multiple modulation of cancer cells, macrophages, and dendritic cells. DNGs were first prepared through a reverse\u2010phase microemulsion technique using toyocamycin (Toy)\u2010conjugated generation 3 poly(amidoamine) dendrimers as monomers and terephthalaldehyde\u2010polyethylene glycol\u2010benzaldehyde as a crosslinker, in\u2010situ loaded with gold nanoparticles (Au NPs), physically loaded with an immune adjuvant CpG, and lastly coated with cancer cell\u2010derived Exos. The formed Au\u2010DNGs\/CpG@Exo have a size of 111.6\u00a0nm and pH\u2010responsive Toy release property under a TME\u2010mimetic environment. The nanovaccine enables homologous tumor targeting delivery of Toy to mediate chemotherapy for immunogenic cell death (ICD) induction, and delivery of adjuvant\/Exo\u2010derived antigens to dendritic cells for triple ICD\u2010, adjuvant\u2010 and antigen\u2010mediated maturation. Meanwhile, the loaded Au NPs remodel the immunosuppressive microenvironment through macrophage M1 repolarization\/lysosomal dysfunction to boost immune activation. Such biomimetic DNGs enable effective tumor inhibition and recurrence prevention in a pancreatic tumor mouse model, and may be developed as a therapeutic nanovaccine to tackle other cancer types through reprogramming of multiple cells.<\/jats:p>","DOI":"10.1002\/adfm.202526444","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:21:32Z","timestamp":1771147292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Exosome\u2010Camouflaged pH\u2010Responsive Dendrimer Nanogels as a Therapeutic Vaccine Against Pancreatic Cancer Through Reprogramming of Multiple Cell Types"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-7504","authenticated-orcid":false,"given":"Yanying","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and 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Engineering Donghua University  Shanghai China"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai China"}]},{"given":"Caiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai China"}]},{"given":"Meijuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai General 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