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In this study, amine\u2010terminated generation 5 poly(amidoamine) (PAMAM) dendrimers modified with fluorescein isothiocyanate (FI) and folic acid (FA) were covalently linked to acid\u2010treated MWCNTs, followed by acetylation of the remaining dendrimer terminal amines to neutralize the positive surface potential. The formed multifunctional MWCNTs (MWCNT\/G5.NHAc\u2010FI\u2010FA) were characterized via different techniques. Then, the MWCNT\/G5.NHAc\u2010FI\u2010FA was used to load DOX for targeted and pH\u2010responsive delivery to cancer cells overexpressing high\u2010affinity folic acid receptors (FAR). We showed that the MWCNT\/G5.NHAc\u2010FI\u2010FA enabled a high drug payload and encapsulation efficiency both up to 97.8% and the formed DOX\/MWCNT\/G5.NHAc\u2010FI\u2010FA complexes displayed a pH\u2010responsive release property with fast DOX release under acidic environment and slow release at physiological pH conditions. Importantly, the DOX\/MWCNT\/G5.NHAc\u2010FI\u2010FA complexes displayed effective therapeutic efficacy, similar to that of free DOX, and were able to target to cancer cells overexpressing high\u2010affinity FAR and effectively inhibit the growth of the cancer cells. The synthesized multifunctional dendrimer\u2010modified MWCNTs may be used as a targeted and pH\u2010responsive delivery system for targeting therapy of different types of cancer cells.<\/jats:p>","DOI":"10.1002\/adhm.201200389","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T11:34:59Z","timestamp":1362051299000},"page":"1267-1276","source":"Crossref","is-referenced-by-count":116,"title":["Targeted and pH\u2010Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer\u2010Modified Multi\u2010Walled Carbon 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