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Here, human salivary statherin\u2010inspired genetically engineered recombinamers (ELRs, HSS) on biomedical surfaces regulates mineralization to form an amorphous\u2010calcium\u2010phosphate (ACP) layer that reproduces the original substrate nanotopography. The HSS\u2010ELRs carry a statherin\u2010derived peptide with high affinity to tooth enamel. They are tethered to nanorough surfaces and mineralized using an enzyme\u2010directed process. A homogeneous layer of ACP\u2010minerals forms on HSS\u2010coated surfaces retaining the original nanotopography of the substrate. In contrast, biomineralization of control surfaces results in uncontrolled growth of minerals. This suggest the statherin\u2010inspired ELRs have ability to induce and control growth of the minerals on the biofunctional surfaces. Likely, the HSS\u2010ELR coating have similar bioactivity to that of statherin in human saliva. The hybrid nanorough surfaces improve adhesion and differentiation of preosteoblasts and show potential for dental and orthopedic implants integration. This method enables the combination and tailoring of nanotopographical and biochemical cues to design functionalized surfaces to investigate and potentially direct the stem cell fate.<\/jats:p>","DOI":"10.1002\/adhm.201400015","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T16:18:00Z","timestamp":1396455480000},"page":"1638-1647","source":"Crossref","is-referenced-by-count":33,"title":["Hybrid Nanotopographical Surfaces Obtained by Biomimetic Mineralization of Statherin\u2010Inspired Elastin\u2010Like Recombinamers"],"prefix":"10.1002","volume":"3","author":[{"given":"Yuping","family":"Li","sequence":"first","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics Department of Restorative Sciences School of Dentistry, University of Minnesota  55455 Minneapolis MN USA"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics Department of Restorative Sciences School of Dentistry, University of Minnesota  55455 Minneapolis MN USA"}]},{"given":"Artur J.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"G. I. R. Bioforge, Edificio I+D University of Valladolid  CIBER\u2010BBN, Paseo de Belen 11 47011 Valladolid Spain"}]},{"given":"Eric D.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Biological Sciences School of Dentistry, University of Minnesota  55455 Minneapolis MN USA"}]},{"given":"Kyle V.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics Department of Restorative Sciences School of Dentistry, University of Minnesota  55455 Minneapolis MN USA"}]},{"given":"J. Carlos","family":"Rodriguez\u2010Cabello","sequence":"additional","affiliation":[{"name":"G. I. R. 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