{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:17:59Z","timestamp":1774318679282,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FCT-Portugal"},{"name":"FEDER-European Regional Development Fund","award":["UID\/QUI\/00313\/2013 and PEst-OE\/QUI\/UI0313\/2014"],"award-info":[{"award-number":["UID\/QUI\/00313\/2013 and PEst-OE\/QUI\/UI0313\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Magnetic resonance imaging is a diagnostic tool used for detecting abnormal organs and tissues, often using Gd(III) complexes as contrast\u2010enhancing agents. In this work, core\u2013shell polymer fibers have been prepared using coaxial electrospinning, with the intent of delivering gadolinium (III) diethylenetriaminepentaacetate hydrate (Gd(DTPA)) selectively to the colon. The fibers comprise a poly(ethylene oxide) (PEO) core loaded with Gd(DTPA), and a Eudragit S100 shell. They are homogeneous, with distinct core\u2013shell phases. The components in the fibers are dispersed in an amorphous fashion. The proton relaxivities of Gd(DTPA) are preserved after electrospinning. To permit easy visualization of the release of the active ingredient from the fibers, analogous materials are prepared loaded with the dye rhodamine B. Very little release is seen in a pH 1.0 buffer, while sustained release is seen at pH 7.4. The fibers thus have the potential to selectively deliver Gd(DTPA) to the colon. Mucoadhesion studies reveal there are strong adhesive forces between porcine colon mucosa and PEO from the core, and the dye\u2010loaded fibers can be successfully used to image the porcine colon wall. The electrospun core\u2013shell fibers prepared in this work can thus be developed as advanced functional materials for effective imaging of colonic abnormalities.<\/jats:p>","DOI":"10.1002\/adhm.201500872","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T07:47:20Z","timestamp":1456127240000},"page":"977-985","source":"Crossref","is-referenced-by-count":46,"title":["Electrospun Contrast\u2010Agent\u2010Loaded Fibers for Colon\u2010Targeted MRI"],"prefix":"10.1002","volume":"5","author":[{"given":"Miao","family":"Jin","sequence":"first","affiliation":[{"name":"UCL School of Pharmacy University College London 29\u201039 Brunswick Square  London WC1N 1AX UK"}]},{"given":"Deng\u2010Guang","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering University of Shanghai for Science and Technology  Shanghai 200093 China"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering University of Shanghai for Science and Technology  Shanghai 200093 China"}]},{"given":"Carlos F. G. C.","family":"Geraldes","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Coimbra Chemistry Center \u2013 CQC Faculty of Science and Technology University of Coimbra  Coimbra 3000\u2010393 Portugal"}]},{"given":"Gareth R.","family":"Williams","sequence":"additional","affiliation":[{"name":"UCL School of Pharmacy University College London 29\u201039 Brunswick Square  London WC1N 1AX UK"}]},{"given":"S. W. 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