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Inhalable polymeric dry powders are promising alternatives as anti\u2010TB drug carriers to the alveoli milieu and infected macrophages, with potential to significantly improve the therapeutics efficiency. Here, the development of a magnetically responsive microparticulate system for pulmonary delivery of an anti\u2010TB drug candidate (P3) is reported. Microparticles (MPs) are developed based on a cast method using calcium carbonate sacrificial templates and incorporate superparamagnetic iron oxide nanoparticles to concentrate MPs in alveoli and enable drug on demand release upon actuation of an external alternate magnetic field (AMF). The MPs are shown to be suitable for P3 delivery to the lower airways and for alveolar macrophage phagocytosis. The developed MPs reveal unique and promising features to be used as an inhalable dry powder allowing the AMF control over dosage and frequency of drug delivery anticipating improved TB treatments.<\/jats:p>","DOI":"10.1002\/adhm.201800124","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T02:40:50Z","timestamp":1527129650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery"],"prefix":"10.1002","volume":"7","author":[{"given":"Margarida S.","family":"Miranda","sequence":"first","affiliation":[{"name":"3B's Research Group I3Bs\u2010Research Institute on Biomaterials, Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia Zona Industrial da Gandra 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's \u2010 PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of Minho  Avepark 4805\u2010017 Barco Guimar\u00e3es Portugal"}]},{"given":"M\u00e1rcia T.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs\u2010Research Institute on Biomaterials, Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia Zona Industrial da Gandra 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's \u2010 PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of Minho  Avepark 4805\u2010017 Barco Guimar\u00e3es Portugal"}]},{"given":"Rui M. 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