{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:54:28Z","timestamp":1776722068362,"version":"3.51.2"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CM1403"],"award-info":[{"award-number":["CM1403"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI\/12\/RC\/2278"],"award-info":[{"award-number":["SFI\/12\/RC\/2278"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["HRZZ\u2010IP\u20102016\u201006\u20102436"],"award-info":[{"award-number":["HRZZ\u2010IP\u20102016\u201006\u20102436"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GO 1968\/5\u20101"],"award-info":[{"award-number":["GO 1968\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The unique photoluminescent properties of upconversion nanoparticles (UCNPs) have attracted worldwide research interest and inspired many bioanalytical applications. The anti\u2010Stokes emission with long luminescence lifetimes, narrow and multiple absorption and emission bands, and excellent photostability enable background\u2010free and multiplexed detection in deep tissues. So far, however, in vitro and in vivo applications of UCNPs are restricted to the laboratory use due to safety concerns. Possible harmful effects may originate from the chemical composition but also from the small size of UCNPs. Potential end users must rely on well\u2010founded safety data. Thus, a risk to benefit assessment of the envisioned combined therapeutic and diagnostic (\u201ctheranostic\u201d) applications is fundamentally important to bridge the translational gap between laboratory and clinics. The COST Action CM1403 \u201cThe European Upconversion Network\u2014From the Design of Photon\u2010Upconverting Nanomaterials to Biomedical Applications\u201d integrates research on UCNPs ranging from fundamental materials synthesis and research, detection instrumentation, biofunctionalization, and bioassay development to toxicity testing. Such an interdisciplinary approach is necessary for a better and safer theranostic use of UCNPs. Here, the status of nanotoxicity research on UCNPs is compared to other nanomaterials, and routes for the translation of UCNPs into clinical applications are delineated.<\/jats:p>","DOI":"10.1002\/adhm.201801233","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T03:46:28Z","timestamp":1544413588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403)"],"prefix":"10.1002","volume":"8","author":[{"given":"Helena","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Biology CESAM\u2010Centre for Environmental and Marine Studies CICECO\u2010Aveiro Institute of Materials University of Aveiro  3810\u2010193 Aveiro Portugal"}]},{"given":"Artur","family":"Bednarkiewicz","sequence":"additional","affiliation":[{"name":"Institute of Low Temperature and Structure Research Polish Academy of Sciences  ul.Okolna 2 50422 Wroclaw Poland"},{"name":"PORT Sp. z o.o.  Stablowicka 147 Str. 54\u2010066 Wroclaw Poland"}]},{"given":"Andreas","family":"Falk","sequence":"additional","affiliation":[{"name":"BioNanoNet Forschungsgesellschaft mbH  Steyrergasse 17 8010 Graz Austria"}]},{"given":"Eleonore","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Center for Medical Research Medical University of Graz  Stiftingtalstrasse 24 8010 Graz Austria"}]},{"given":"Darja","family":"Lisjak","sequence":"additional","affiliation":[{"name":"Department for Materials Synthesis Jo\u017eef Stefan Institute  Jamova 39 1000 Ljubljana Slovenia"}]},{"given":"Adriele","family":"Prina\u2010Mello","sequence":"additional","affiliation":[{"name":"LBCAM and Nanomedicine Laboratory Trinity Translational Medicine Institute Trinity College Dublin  Dublin 8 Republic of Ireland"}]},{"given":"Susanne","family":"Resch","sequence":"additional","affiliation":[{"name":"BioNanoNet Forschungsgesellschaft mbH  Steyrergasse 17 8010 Graz Austria"}]},{"given":"Christa","family":"Schimpel","sequence":"additional","affiliation":[{"name":"BioNanoNet Forschungsgesellschaft mbH  Steyrergasse 17 8010 Graz Austria"}]},{"given":"Ivana Vinkovi\u0107","family":"Vr\u010dek","sequence":"additional","affiliation":[{"name":"Institute for Medical Research and Occupational Health  Ksaverska cesta 2 10000 Zagreb Croatia"}]},{"given":"Edyta","family":"Wysoki\u0144ska","sequence":"additional","affiliation":[{"name":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences  Wroc\u0142aw Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-4293","authenticated-orcid":false,"given":"Hans H.","family":"Gorris","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry Chemo\u2010 and Biosensors University of Regensburg  93040 Regensburg Germany"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-017-0499-z"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-017-0482-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00186A"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020357g"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200400772"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04571-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400425h"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2017.03.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/am.2016.106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.59"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adom.201300160"},{"key":"e_1_2_9_12_1","unstructured":"X.Cheng Y.Pan Z.Yuan X.Wang W.Su L.Yin X.Xie 2018 1800208 1."},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"Y.Zhong I.Rostami Z.Wang H.Dai Z.Hu 2015 940 6418.","DOI":"10.1002\/adma.201502272"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201602514"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201208196"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00173G"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201202433"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00158C"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700508"},{"key":"e_1_2_9_21_1","author":"Buchner M.","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201437"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2017.1279361"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchas.2017.06.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.07.016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-012-0970-x"},{"key":"e_1_2_9_27_1","first-page":"135","volume-title":"Pharmaceutical Nanotechnology: Innovation and Production","author":"Borgos S. E. F.","year":"2017"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813339-2.00017-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b04221"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3996-x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2015.52"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.723"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx200470e"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR01654A"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00514"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.7.23"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06093-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201500437"},{"key":"e_1_2_9_39_1","first-page":"1","volume-title":"Draft Guidance Document on Good In Vitro Method Practices (GIVIMP) for the Development and Implementation of In Vitro Methods for Regulatory Use in Human Safety Assessment","author":"OECD","year":"2017"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA14100A"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1088\/2050-6120\/aae9c8"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00175C"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00177J"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-014-0641-6"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/24\/23\/235702"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201103485"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-012-4671-x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA00902B"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.6b09301"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn406166n"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.045"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR05456D"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR03892A"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.17344\/acsi.2015.1508"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.038"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.09.054"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.5701"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.019"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0185-0"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CP03935F"},{"key":"e_1_2_9_61_1","first-page":"43","volume":"5","author":"Roblegg E.","year":"2011","journal-title":"ASM Sci. J."},{"key":"e_1_2_9_62_1","unstructured":"A.Falk C.Schimpel A.Haase B.Hazebrouck C.Fito A.Prina\u2010Mello K.Savolainen A.Sips J.Pe\u00f1a I.Lynch C.Charitidis V.Germ \u201cCloser to the Market\u201d Roadmap (CTTM) 2016."},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac303636s"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.05.037"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201801233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.201801233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201801233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:46:55Z","timestamp":1759744015000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201801233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/adhm.201801233"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201801233","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,10]]},"assertion":[{"value":"2018-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1801233"}}