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The outstanding outcomes of the systemic administration of antibodies (Abs) are narrowed by the risk of serious side effects and limited efficacy due to their short half\u2010life. Interleukin\u201023 (IL\u201023) is a crucial pro\u2010inflammatory cytokine involved in inflammation that potently enhances the generation of T\u2010helper type\u201017 (Th17) cells. Hence, in this work, anti\u2010IL\u201023 Abs are immobilized at the surface of liposomes to increase their therapeutic efficacy, being gold nanoparticles (AuNPs) incorporated to allow monitoring the biodistribution of the liposomes after systemic administration as well as due to their anti\u2010inflammatory and antioxidant effects. A stable monodispersed liposomes\u2019 suspension with around 130\u00a0nm is produced and efficiently biofunctionalized with anti\u2010IL\u201023 Abs. IL\u201023 capture and neutralization capacity are confirmed using activated macrophages. Biological assays demonstrate their hemocompatibility and cytocompatibility with human articular chondrocytes, macrophages, and endothelial cells. Moreover, the neutralization of IL\u201023 by the biofunctionalized liposomes efficiently decreases the production of IL\u201017A by peripheral blood mononuclear cells of healthy donors and RA patients who are activated to Th17 differentiation. Therefore, the developed formulation may be a promising strategy to treat RA.<\/jats:p>","DOI":"10.1002\/adhm.202001570","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T04:02:20Z","timestamp":1603684940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Biofunctionalized Liposomes to Monitor Rheumatoid Arthritis Regression Stimulated by Interleukin\u201023 Neutralization"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9102-6235","authenticated-orcid":false,"given":"Ana Cl\u00e1udia","family":"Lima","sequence":"first","affiliation":[{"name":"3B's Research Group I3Bs\u2014Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia Zona Industrial da Gandra  Barco 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