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Here, a novel therapeutic approach based on vertically aligned carbon nanotube forests (VA\u2010CNT forests) and periodic VA\u2010CNT micropillars produced by thermal chemical vapor deposition is explored. In addition, honeycomb\u2010like and flower\u2010like morphologies are created. Initial viability testing reveals that NE\u20104C neural stem cells seeded on all morphologies survive and proliferate. In addition, free\u2010standing VA\u2010CNT forests and capillary\u2010driven VA\u2010CNT forests are created, with the latter demonstrating enhanced capacity to stimulate neuritogenesis and network formation under minimal differentiation medium conditions. This is attributed to the interaction between surface roughness and 3D\u2010like morphology that mimics the native extracellular matrix, thus enhancing cellular attachment and communication. These findings provide a new avenue for the construction of electroresponsive scaffolds based on CNTs for neural tissue engineering.<\/jats:p>","DOI":"10.1002\/adhm.202300828","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T02:10:05Z","timestamp":1686708605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Customizing 3D Structures of Vertically Aligned Carbon Nanotubes to Direct Neural Stem Cell Differentiation"],"prefix":"10.1002","volume":"12","author":[{"given":"Lu\u00eds","family":"Nascimento","sequence":"first","affiliation":[{"name":"TEMA Mechanical Engineering Department University of Aveiro  Aveiro 3810\u2010193 Portugal"},{"name":"Intelligent Systems Associate Laboratory (LASI)  Aveiro 3810\u2010193 Portugal"}]},{"given":"Cristiana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"TEMA Mechanical Engineering Department University of Aveiro  Aveiro 3810\u2010193 Portugal"},{"name":"Intelligent Systems Associate Laboratory (LASI)  Aveiro 3810\u2010193 Portugal"}]},{"given":"Ricardo. 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