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With a novel approach, a series of porous manganese\u2010iron PB (MnPB) colloids, which are shown to be efficient scavengers for reactive oxygen species (ROS) including hydroxyl radical, superoxide anion, and hydrogen peroxide, are prepared. In vitro cellular experiments confirm the capability of the nanozyme to protect cells from ROS attack. In vivo, the administration of MnPB nanozyme through gavage at a dosage of 10\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> per day for three doses in total potently ameliorates the pathological symptoms of acute UC in a murine model, resulting in mitigated inflammatory responses and improved viability rate. Significantly, the nanozyme produced at a large scale can be achieved at an unprecedented yield weighting \u224811\u00a0g per batch of reaction, demonstrating comparable anti\u2010ROS activities and treatment efficacy to its small\u2010scale counterpart. 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