{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:32:18Z","timestamp":1777674738391,"version":"3.51.4"},"reference-count":448,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21371115"],"award-info":[{"award-number":["21371115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11025526"],"award-info":[{"award-number":["11025526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21671131"],"award-info":[{"award-number":["21671131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11875185"],"award-info":[{"award-number":["11875185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00347\/2015"],"award-info":[{"award-number":["IF\/00347\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advantages such as strong signal strength, resistance to photobleaching, tunable fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for the application of fluorescent nanoparticles (FNPs) in cancer diagnosis and therapy. In addition, the large surface area and easy modification of FNPs provide a platform for the design of multifunctional nanoparticles (MFNPs) for tumor targeting, diagnosis, and treatment. In order to obtain better targeting and therapeutic effects, it is necessary to understand the properties and targeting mechanisms of FNPs, which are the foundation and play a key role in the targeting design of nanoparticles (NPs). Widely accepted and applied targeting mechanisms such as enhanced permeability and retention (EPR) effect, active targeting, and tumor microenvironment (TME) targeting are summarized here. Additionally, a freshly discovered targeting mechanism is introduced, termed cell membrane permeability targeting (CMPT), which improves the tumor\u2010targeting rate from less than 5% of the EPR effect to more than 50%. A new design strategy is also summarized, which is promising for future clinical targeting NPs\/nanomedicines design. The targeting mechanism and design strategy will inspire new insights and thoughts on targeting design and will speed up precision medicine and contribute to cancer therapy and early diagnosis.<\/jats:p>","DOI":"10.1002\/adma.201902409","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T11:49:55Z","timestamp":1564660195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":231,"title":["Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment"],"prefix":"10.1002","volume":"31","author":[{"given":"Jiuyang","family":"He","sequence":"first","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Biophysics Chinese Academy of Sciences  Beijing 100101 P. R. China"}]},{"given":"Chenchen","family":"Li","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Department of Biological Chemistry The University of Michigan  Ann Arbor MI 48109 USA"}]},{"given":"Yanan","family":"Huang","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"}]},{"given":"Xuelian","family":"Yin","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Universal Medical Imaging Diagnostic Research Center  Shanghai 200233 P. R. China"}]},{"given":"Chenjie","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Harvard T. H. Chan School of Public Health Harvard University  Boston MA 02115 USA"}]},{"given":"Minmin","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Biophysics Chinese Academy of Sciences  Beijing 100101 P. R. China"}]},{"given":"Rog\u00e9rio P.","family":"Pirraco","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs \u2010 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark Parque de Ci\u00eancia e Tecnologia  Zona Industrial da Gandra 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Lab  4805 Braga\/Guimar\u00e3es Portugal"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"}]},{"given":"Quan","family":"Lu","sequence":"additional","affiliation":[{"name":"Harvard T. H. Chan School of Public Health Harvard University  Boston MA 02115 USA"}]},{"given":"Ryan","family":"Baldridge","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry The University of Michigan  Ann Arbor MI 48109 USA"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Department of Biomedical Engineering National University of Singapore  Singapore 119077 Singapore"}]},{"given":"Minghong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-6129","authenticated-orcid":false,"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3B's Research Group I3Bs \u2010 Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark Parque de Ci\u00eancia e Tecnologia  Zona Industrial da Gandra 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Lab  4805 Braga\/Guimar\u00e3es Portugal"},{"name":"The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of Minho  Avepark 4805\u2010017 Barco Guimar\u00e3es Portugal"}]},{"given":"Yanli","family":"Wang","sequence":"additional","affiliation":[{"name":"Tumor Precision Targeting Research Center School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 P. R. China"},{"name":"Harvard T. H. Chan School of Public Health Harvard University  Boston MA 02115 USA"}]}],"member":"311","published-online":{"date-parts":[[2019,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01202a519"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194806032382301"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241145"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60721-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2007.10.012"},{"key":"e_1_2_8_4_1","first-page":"481","volume":"9","author":"Akakuru O. U.","year":"2018","journal-title":"J. Nanomed. Nanotechnol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00392F"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_8_6_1","first-page":"311","volume":"77","author":"Gerber D. E.","year":"2008","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc903"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.18433\/J30C7D"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01153B"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00719H"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.302"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35313J"},{"key":"e_1_2_8_9_4","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00413J"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.08.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00321"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22602"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60433K"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460500400603"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.134"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1210-957"},{"key":"e_1_2_8_14_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2013.03.005"},{"key":"e_1_2_8_14_5","doi-asserted-by":"publisher","DOI":"10.3390\/nano6040076"},{"key":"e_1_2_8_14_6","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14998"},{"key":"e_1_2_8_14_7","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22430"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.09.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2009.11.002"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12626"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp100301t"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-anchem-060908-155136"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.11.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2017.02.005"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.20170377"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2NR32311G"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000418"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr33849e"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-011-0056-5"},{"key":"e_1_2_8_23_3","doi-asserted-by":"publisher","DOI":"10.1021\/nn401196a"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05575"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00587F"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA04096E"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0452-z"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200305622"},{"key":"e_1_2_8_26_3","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc16306c"},{"key":"e_1_2_8_26_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.08.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1248"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46581-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46581-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.445834"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt927"},{"key":"e_1_2_8_29_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104274"},{"key":"e_1_2_8_29_4","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1390"},{"key":"e_1_2_8_29_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.03.015"},{"key":"e_1_2_8_29_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.004"},{"key":"e_1_2_8_29_7","doi-asserted-by":"publisher","DOI":"10.1021\/ar9001069"},{"key":"e_1_2_8_29_8","doi-asserted-by":"publisher","DOI":"10.1039\/c3an36705c"},{"key":"e_1_2_8_29_9","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00532E"},{"key":"e_1_2_8_29_10","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.11.189"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900626"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/B9NR00160C"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2011.06.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.02.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NJ01761H"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201204419"},{"key":"e_1_2_8_33_3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15130"},{"key":"e_1_2_8_33_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn202378b"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800662"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.071"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00156b"},{"key":"e_1_2_8_36_3","doi-asserted-by":"publisher","DOI":"10.1021\/ja412152x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807456"},{"key":"e_1_2_8_38_1","first-page":"6387","volume":"46","author":"Matsumura Y.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12228"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b00021"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.04.009"},{"key":"e_1_2_8_40_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.04.008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.11.015"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.10.002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.013"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342130-00002"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.03.011"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.005"},{"key":"e_1_2_8_47_1","first-page":"164","volume":"29","author":"Li J. C.","year":"2015","journal-title":"Chin. J. Pharmacol. Toxicol."},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics3010034"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.07.015"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.3.5.703"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc200111p"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.04.009"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01320"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.018"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.05.046"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00044-3"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.03.018"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.134"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0482478"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.3.4.579"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc100241a"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.12.014"},{"key":"e_1_2_8_58_1","first-page":"3106","volume":"31","author":"Xie J.","year":"2010","journal-title":"Biomaterials"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.04.036"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn800448r"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1381"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2018.02.003"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2005.04.008"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt994"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2014.1989"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018382108"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003379107"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b11154"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.064"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07866"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5596"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/354056a0"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar0101640"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.10.002"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014501108"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja809086q"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70161-4"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl072949q"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707654105"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201200133"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl062306v"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2006.170"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2766"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00359j"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC47512C"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac503636j"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300189"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.14.3312"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.7.2445"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.8.2353"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.139"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.083998"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616895113"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00437"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<751::AID-CNCR2820560409>3.0.CO;2-Y"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp074"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199701150-00008"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-014-1767-3"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.005"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201301656"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn800781r"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03549F"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201500580"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn800072t"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.051"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stam.2006.09.008"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4NJ00416G"},{"key":"e_1_2_8_102_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.05.071"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl802223f"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.10.051"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200802261"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.015"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.12.050"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.09.069"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn402399m"},{"key":"e_1_2_8_108_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201765"},{"key":"e_1_2_8_108_4","doi-asserted-by":"publisher","DOI":"10.1038\/srep10785"},{"key":"e_1_2_8_108_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.004"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC00098K"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201400961"},{"key":"e_1_2_8_110_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR06756A"},{"key":"e_1_2_8_110_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.08.058"},{"key":"e_1_2_8_110_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.02.009"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900725"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.10.076"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b03709"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.034"},{"key":"e_1_2_8_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.10.024"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.075"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn700370b"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201002300"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA20903C"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201402297"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn901297q"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn501816z"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.11.008"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.012"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.00170.x"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2008.04.001"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-014-2784-5"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b05775"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b07425"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.11.041"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099314"},{"key":"e_1_2_8_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.12.020"},{"key":"e_1_2_8_129_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2088"},{"key":"e_1_2_8_129_4","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.14.5535"},{"key":"e_1_2_8_129_5","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0592"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.03.033"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.07.001"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR06533G"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.01.006"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200805998"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201203106"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40989"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.4690"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn301218z"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/24\/13\/135101"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.083"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.017"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.08.017"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac901960d"},{"key":"e_1_2_8_143_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300102"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR03374H"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.294"},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014501108"},{"key":"e_1_2_8_145_3","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-009-9009-8"},{"key":"e_1_2_8_145_4","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2008.231"},{"key":"e_1_2_8_145_5","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1501"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b04373"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja404243v"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.10.032"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.12.050"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn2013707"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA27411G"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201503453"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.05.018"},{"key":"e_1_2_8_152_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.174"},{"key":"e_1_2_8_152_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01530"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.12.003"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.54.101601.152442"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00666177"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.07.038"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048248"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201200080"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn2032177"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909109018953"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.08.004"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.139"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200800714"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12117410"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.202"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2nr32047a"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn900491j"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4393-7"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200526m"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/346818a0"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1039\/b901729a"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809154105"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.312"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja5029364"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.058"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc14652a"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1NR11265A"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-014-0763-y"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2614"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S596"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6204"},{"key":"e_1_2_8_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.02.007"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.185363"},{"key":"e_1_2_8_183_1","first-page":"98","volume":"8","author":"Paget S.","year":"1989","journal-title":"Cancer. Metastasis. Rev."},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2016.06.006"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b04236"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00336-2"},{"key":"e_1_2_8_186_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1478"},{"key":"e_1_2_8_186_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2011.09.001"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1955.55"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5510"},{"key":"e_1_2_8_188_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.2.149"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC03454G"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja105937q"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305784"},{"key":"e_1_2_8_191_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC05518K"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC02972H"},{"key":"e_1_2_8_192_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.610"},{"key":"e_1_2_8_192_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2509"},{"key":"e_1_2_8_192_4","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6834"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-009-9026-7"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308368"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC47324D"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201100884"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.12.037"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00592F"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0866"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.10.016"},{"key":"e_1_2_8_200_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0520"},{"key":"e_1_2_8_200_3","doi-asserted-by":"publisher","DOI":"10.1002\/stem.504"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.02.013"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1256"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061646"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9692"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14293"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.035"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn304872n"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201501779"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b06969"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.12.009"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR05278B"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.08.020"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b02641"},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07075"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08303"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b03506"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0006"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR00888K"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.7b00047"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB00931G"},{"key":"e_1_2_8_221_1","first-page":"1641","volume":"2","author":"Jia X.","year":"2016","journal-title":"Engineering"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11760"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2018.02.017"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201600261"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06695"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.04.024"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3819"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b02031"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S123386"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b00036"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05113-8"},{"key":"e_1_2_8_233_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8284"},{"key":"e_1_2_8_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1340"},{"key":"e_1_2_8_235_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn901146y"},{"key":"e_1_2_8_236_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007321"},{"key":"e_1_2_8_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000538"},{"key":"e_1_2_8_238_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-10-21"},{"key":"e_1_2_8_238_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2004.146"},{"key":"e_1_2_8_238_3","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2006.170"},{"key":"e_1_2_8_238_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.08.096"},{"key":"e_1_2_8_238_5","doi-asserted-by":"publisher","DOI":"10.1021\/nn1024303"},{"key":"e_1_2_8_239_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja401612x"},{"key":"e_1_2_8_240_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201304465"},{"key":"e_1_2_8_241_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201403095"},{"key":"e_1_2_8_242_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4030898"},{"key":"e_1_2_8_243_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4030898"},{"key":"e_1_2_8_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.028"},{"key":"e_1_2_8_245_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b07129"},{"key":"e_1_2_8_246_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn401911k"},{"key":"e_1_2_8_247_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802748"},{"key":"e_1_2_8_248_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201402964"},{"key":"e_1_2_8_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.011"},{"key":"e_1_2_8_250_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201206059"},{"key":"e_1_2_8_251_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900547"},{"key":"e_1_2_8_252_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00038"},{"key":"e_1_2_8_253_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050293"},{"key":"e_1_2_8_253_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70130-9"},{"key":"e_1_2_8_253_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.141"},{"key":"e_1_2_8_253_4","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111703"},{"key":"e_1_2_8_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02060-8"},{"key":"e_1_2_8_254_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3987"},{"key":"e_1_2_8_255_1","doi-asserted-by":"publisher","DOI":"10.2307\/1543609"},{"key":"e_1_2_8_255_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2003.08.007"},{"key":"e_1_2_8_256_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400821111"},{"key":"e_1_2_8_256_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2472"},{"key":"e_1_2_8_256_3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003757"},{"key":"e_1_2_8_257_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja303737a"},{"key":"e_1_2_8_258_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc900323v"},{"key":"e_1_2_8_259_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04222-8"},{"key":"e_1_2_8_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.12.002"},{"key":"e_1_2_8_261_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2014.1799"},{"key":"e_1_2_8_262_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08900"},{"key":"e_1_2_8_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.08.029"},{"key":"e_1_2_8_264_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01157"},{"key":"e_1_2_8_265_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0359-9"},{"key":"e_1_2_8_266_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.201600393"},{"key":"e_1_2_8_267_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201301239"},{"key":"e_1_2_8_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.05.003"},{"key":"e_1_2_8_269_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC01251E"},{"key":"e_1_2_8_270_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b02014"},{"key":"e_1_2_8_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.11.025"},{"key":"e_1_2_8_272_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b03507"},{"key":"e_1_2_8_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2014.10.027"},{"key":"e_1_2_8_274_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-2643-x"},{"key":"e_1_2_8_275_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201402522"},{"key":"e_1_2_8_276_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b15583"},{"key":"e_1_2_8_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2014.10.034"},{"key":"e_1_2_8_278_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7AN02040F"},{"key":"e_1_2_8_279_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja412380j"},{"key":"e_1_2_8_280_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR02429D"},{"key":"e_1_2_8_281_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA10409F"},{"key":"e_1_2_8_282_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2933"},{"key":"e_1_2_8_283_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10432"},{"key":"e_1_2_8_284_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl100996u"},{"key":"e_1_2_8_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.06.013"},{"key":"e_1_2_8_286_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b01011"},{"key":"e_1_2_8_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.08.034"},{"key":"e_1_2_8_288_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7DT02791E"},{"key":"e_1_2_8_289_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc400131a"},{"key":"e_1_2_8_290_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06777"},{"key":"e_1_2_8_291_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.226"},{"key":"e_1_2_8_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0006-z"},{"key":"e_1_2_8_293_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1490019"},{"key":"e_1_2_8_294_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000213"},{"key":"e_1_2_8_294_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.10.009"},{"key":"e_1_2_8_295_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0011-0"},{"key":"e_1_2_8_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.030"},{"key":"e_1_2_8_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.016"},{"key":"e_1_2_8_297_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80010"},{"key":"e_1_2_8_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.061"},{"key":"e_1_2_8_299_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.244"},{"key":"e_1_2_8_300_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00473K"},{"key":"e_1_2_8_301_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01050-0"},{"key":"e_1_2_8_302_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13193"},{"key":"e_1_2_8_303_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03473-9"},{"key":"e_1_2_8_304_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818357116"},{"key":"e_1_2_8_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.02.010"},{"key":"e_1_2_8_306_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2018.29"},{"key":"e_1_2_8_307_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b03442"},{"key":"e_1_2_8_307_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04547"},{"key":"e_1_2_8_307_3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b11311"},{"key":"e_1_2_8_307_4","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08645"},{"key":"e_1_2_8_307_5","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08518"},{"key":"e_1_2_8_307_6","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.23"},{"key":"e_1_2_8_307_7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220817110"},{"key":"e_1_2_8_308_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08554-x"},{"key":"e_1_2_8_309_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0987-8"},{"key":"e_1_2_8_310_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201303631"},{"key":"e_1_2_8_311_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-2008-4603"},{"key":"e_1_2_8_311_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00294F"},{"key":"e_1_2_8_311_3","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00030K"},{"key":"e_1_2_8_311_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2012.10.006"},{"key":"e_1_2_8_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.017"},{"key":"e_1_2_8_312_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403202"},{"key":"e_1_2_8_313_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.18.008867"},{"key":"e_1_2_8_313_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.9.090501"},{"key":"e_1_2_8_313_3","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.6.061202"},{"key":"e_1_2_8_313_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201502285"},{"key":"e_1_2_8_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.08.049"},{"key":"e_1_2_8_315_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja505412p"},{"key":"e_1_2_8_316_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn500722y"},{"key":"e_1_2_8_317_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB02979E"},{"key":"e_1_2_8_317_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201803321"},{"key":"e_1_2_8_317_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201101447"},{"key":"e_1_2_8_317_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07866"},{"key":"e_1_2_8_318_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja806242t"},{"key":"e_1_2_8_318_2","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2012.263"},{"key":"e_1_2_8_318_3","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2014.145"},{"key":"e_1_2_8_318_4","doi-asserted-by":"publisher","DOI":"10.1021\/ja300140c"},{"key":"e_1_2_8_319_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.05.011"},{"key":"e_1_2_8_320_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.04.004"},{"key":"e_1_2_8_321_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.04.053"},{"key":"e_1_2_8_322_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b15505"},{"key":"e_1_2_8_323_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.030"},{"key":"e_1_2_8_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2018.05.022"},{"key":"e_1_2_8_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.006"},{"key":"e_1_2_8_326_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807602"},{"key":"e_1_2_8_327_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.03.005"},{"key":"e_1_2_8_328_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.09.026"},{"key":"e_1_2_8_329_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201602309"},{"key":"e_1_2_8_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.05.030"},{"key":"e_1_2_8_331_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.031"},{"key":"e_1_2_8_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.015"},{"key":"e_1_2_8_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.058"},{"key":"e_1_2_8_334_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201500323"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadma.201902409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201902409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.201902409","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.201902409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:19:03Z","timestamp":1759760343000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.201902409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":448,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/adma.201902409"],"URL":"https:\/\/doi.org\/10.1002\/adma.201902409","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2019-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1902409"}}