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Gut microbiota secrete abundant extracellular vesicles (Gm\u2010EVs), which play a critical role in bacteria\u2010to\u2010bacteria and bacteria\u2010to\u2010host communications. Herein, intestinal microbiota are trained using tea leaf lipid\/pluronic F127\u2010coated curcumin nanocrystals (CN@Lp<jats:sub>127<\/jats:sub>s), which can maintain stability during transit through the gastrointestinal tract. Compared with FMT, Gm\u2010EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring colonic barrier function, and rebalancing intestinal microbiota. Strikingly, Gm\u2010EVs obtained from CN@Lp<jats:sub>127<\/jats:sub>\u2010trained healthy mice exhibit a superior therapeutic effect on UC compared to groups receiving FMT from healthy mice, Gm\u2010EVs from healthy mice, and FMT from CN@Lp<jats:sub>127<\/jats:sub>\u2010trained healthy mice. 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