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Hard protein corona (HC)\u2010dependent bio\u2010nano interactions are highly sensitive to material surface functional group changes. Alterations in HC change the colloidal stability of the nanomaterials hence changes the material presentation to cells, which ultimately affect bio\u2010nano interactions. Here graphene oxide (GO) is used as an exemplar 2D platform to investigate HC\u2010dependent and colloidal stability\u2010dependent bio\u2010nano interactions on contrasting non\u2010phagocytic A549 cells and phagocytic J774 cells, using lactate dehydrogenase (LDH) assay and principal components analysis (PCA) of cellular IR spectra obtained by label\u2010free synchrotron radiation\u2010based Fourier\u2010transform IR microspectroscopy (SR\u2010FTIR).<\/jats:p>","DOI":"10.1002\/admi.202100251","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T02:47:08Z","timestamp":1628822828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interpreting 2D Materials Bio\u2010Nano Interactions: Influence of Aggregation Status, Protein Corona, Cell Culture Media, and Cell Types"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-2154","authenticated-orcid":false,"given":"Kuo\u2010Ching","family":"Mei","sequence":"first","affiliation":[{"name":"School of Cancer &amp; 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