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Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure\u2010assisted sintering technique is employed to impregnate beta\u2010tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone\u2010implant fixation and osseointegration are assessed, by performing push\u2010out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push\u2010out forces are higher for the textured and multi\u2010material solution, when compared to non\u2010textured implants right after 4 weeks of implantation (<jats:italic>p<\/jats:italic>\u00a0&lt; 0.05). After 12 weeks, multi\u2010material implant displayed higher fracture energy when compared to non\u2010textured implants (<jats:italic>p<\/jats:italic>\u00a0&lt; 0.05). Results revealed that laser surface texturing and bioactive multi\u2010material solutions are highly effective to promote bone regeneration and enhance bone\u2010implant fixation for further application in orthopedic implants.<\/jats:p>","DOI":"10.1002\/admt.202101117","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:46:43Z","timestamp":1641170803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Osseointegration Assessment of Multi\u2010Material Ti6Al4V\u2010\u03b2\u2009TCP Implants: An Experimental Study in Rats"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-3883","authenticated-orcid":false,"given":"Mafalda M.","family":"Costa","sequence":"first","affiliation":[{"name":"Center for MicroElectroMechanical Systems (CMEMS\u2010UMinho) University of Minho  Campus de Azur\u00e9m Guimar\u00e3es 4800\u2010058 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