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A flow enzymatic kinetic resolution of the resulting bicyclic vinyl aziridine delivered the enantiopure precursor to the natural product. This total synthesis required the use of a single protective group. Two novel agelastatin <jats:italic>N3<\/jats:italic>\u2010derivatives were synthesized and their cytotoxicity evaluated against a series of cancer cell lines, which corroborated the importance of unsubstituted <jats:italic>N3<\/jats:italic> in the biological activity of (\u2212)\u2010agelastatin A.<\/jats:p>","DOI":"10.1002\/adsc.202300560","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T22:55:36Z","timestamp":1685660136000},"page":"2240-2247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["From Pyridine to (\u2212)\u2010Agelastatin A"],"prefix":"10.1002","volume":"365","author":[{"given":"Jo\u00e3o R.","family":"Vale","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy Universidade de Lisboa  Av. 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