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The aim of this work is to devise an integrated strategy to valorize EOP by applying two\u2010step extraction, and to evaluate the effect of an ethanol organosolv pretreatment on the delignification and enzymatic hydrolysis of the extracted EOP. Once the extraction and organosolv pretreatment conditions are selected, solubilized lignin is recovered from the pretreatment liquor using different methods. In addition to those organosolv lignin samples, a lignin\u2010rich solid is obtained after enzymatic saccharification of the pretreated solid. All the lignin samples are fully characterized aiming at further valorization. The selected two\u2010step aqueous extraction (85 \u00b0C, 90 min, 10% biomass) removes 89% of the extractives content in raw EOP and achieves the full recovery of phenols and mannitol content in that fraction, 4.7 mg gallic acid equivalents per g EOP and 4.5 mg g<jats:sup>\u22121<\/jats:sup> EOP, respectively. The organosolv pretreatment (50% ethanol catalyzed with 1% H<jats:sub>2<\/jats:sub>SO<jats:sub>4<\/jats:sub>, 140 \u00b0C, 60 min, 15% biomass) results in a delignified solid with 81% of enzymatic digestibility and a high purity organosolv lignin (&gt;71%), rich in guaiacyl units.<\/jats:p>","DOI":"10.1002\/adsu.202100361","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T04:14:34Z","timestamp":1643084074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combined Extraction and Ethanol Organosolv Fractionation of Exhausted Olive Pomace for Bioactive Compounds"],"prefix":"10.1002","volume":"6","author":[{"given":"Irene","family":"G\u00f3mez\u2010Cruz","sequence":"first","affiliation":[{"name":"Department of Chemical Environmental and Materials Engineering and Centre for Advanced Studies in Earth Sciences Energy and Environment (CEACTEMA) Universidad de Ja\u00e9n  Campus Las Lagunillas Ja\u00e9n 23071 Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-8034","authenticated-orcid":false,"given":"Inmaculada","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Chemical Environmental and Materials Engineering and Centre for Advanced Studies in Earth Sciences Energy and Environment (CEACTEMA) Universidad de Ja\u00e9n  Campus Las Lagunillas Ja\u00e9n 23071 Spain"}]},{"given":"Mar\u00eda del Mar","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Chemical Environmental and Materials Engineering and Centre for Advanced Studies in Earth Sciences Energy and Environment (CEACTEMA) Universidad de Ja\u00e9n  Campus Las Lagunillas Ja\u00e9n 23071 Spain"}]},{"given":"Jalel","family":"Labidi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Environmental Engineering University of the Basque Country (UPV\/EHU)  Plaza Europa 1 San Sebastian 20018 Spain"}]},{"given":"Fabio","family":"Hern\u00e1ndez\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Chemical and Environmental Engineering University of the Basque Country (UPV\/EHU)  Plaza Europa 1 San Sebastian 20018 Spain"}]},{"given":"Luisa B.","family":"Roseiro","sequence":"additional","affiliation":[{"name":"Unidade de Bioenergia e Biorrefinarias LNEG \u2013 Laborat\u00f3rio Nacional de Energia e Geologia  Estrado do Pa\u00e7o do Lumiar, 22 Lisboa 1649\u2010038 Portugal"}]},{"given":"Lu\u00eds C.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Unidade de Bioenergia e Biorrefinarias LNEG \u2013 Laborat\u00f3rio Nacional de Energia e Geologia  Estrado do Pa\u00e7o do Lumiar, 22 Lisboa 1649\u2010038 Portugal"}]},{"given":"Eulogio","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Chemical Environmental and Materials Engineering and Centre for Advanced Studies in Earth Sciences Energy and Environment (CEACTEMA) Universidad de Ja\u00e9n  Campus Las Lagunillas Ja\u00e9n 23071 Spain"}]},{"given":"Florbela","family":"Carvalheiro","sequence":"additional","affiliation":[{"name":"Unidade de Bioenergia e Biorrefinarias LNEG \u2013 Laborat\u00f3rio Nacional de Energia e Geologia  Estrado do Pa\u00e7o do Lumiar, 22 Lisboa 1649\u2010038 Portugal"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-019-1529-1"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111704"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.09.054"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2018.11.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2016.06.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2020.02.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2020.10.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wasman.2020.06.017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psep.2021.01.012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/en14113052"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151018349"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10010111"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2021.01.042"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12649-017-0028-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/en14041127"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.11.067"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.04.063"},{"key":"e_1_2_8_18_1","first-page":"95","volume":"47","author":"Guti\u00e9rrez\u2010Villanueva A.","year":"2020","journal-title":"Cent. 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