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Furandicarboxylic acid (FDCA) is one of the key building blocks for producing biobased polymers. However, most studies predominantly focus on 2,5\u2010FDCA, while FDCA encompasses other noteworthy isomers, namely, 2,4\u2010 and 3,4\u2010FDCA. The polymers derived from these two isomers have recently gained attention due to their promising properties. In this study, an environmentally friendly approach for producing biobased polyesters from 2,5\u2010, 2,4\u2010, and 3,4\u2010FDCA dimethyl ester isomers is proposed. The synthesis is conducted under greener conditions, utilizing <jats:italic>Candida antarctica<\/jats:italic> lipase B (CALB) enzyme as a biocatalyst. The performance of the enzyme is assessed, revealing CALB preference for polymerizing 2,5\u2010FDCA over 2,4\u2010 and 3,4\u2010FDCA dimethyl ester, which is elucidated by docking analysis. Moreover, CALB shows varying rates of cyclic oligomer formation for each isomer, favoring 2,5\u2010FDCA cyclization. The structure\u2010property relationship, encompassing the variation in isomeric structure, is evaluated through structural characterization, thermal analysis, and surface properties. This study primarily emphasized enzymatic polymerization and highlighted its versatility in accommodating different monomer isomeric substitutions.<\/jats:p>","DOI":"10.1002\/adsu.202300542","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T03:03:56Z","timestamp":1708830236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unraveling The Impact of Isomerism on Enzymatic Polymerization of Furanic Polyesters"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-4183","authenticated-orcid":false,"given":"Fitrilia","family":"Silvianti","sequence":"first","affiliation":[{"name":"Macromolecular Chemistry &amp; New Polymeric Materials Zernike Institute for Advanced Materials University of Groningen  Nijenborgh 4 Groningen 9747 AG The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-0322","authenticated-orcid":false,"given":"Dina","family":"Maniar","sequence":"additional","affiliation":[{"name":"Macromolecular Chemistry &amp; New Polymeric Materials Zernike Institute for Advanced Materials University of Groningen  Nijenborgh 4 Groningen 9747 AG The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-2704","authenticated-orcid":false,"given":"Beatriz","family":"Agostinho","sequence":"additional","affiliation":[{"name":"CICECO\u2014Aveiro Institute of Materials Department of Chemistry University of Aveiro  Aveiro 3810\u2010193 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-2819","authenticated-orcid":false,"given":"Tijn C.","family":"de Leeuw","sequence":"additional","affiliation":[{"name":"CarbExplore Research B.V.  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