{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:57:46Z","timestamp":1772117866810,"version":"3.50.1"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00293\/2015"],"award-info":[{"award-number":["IF\/00293\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["CheSSTaG 769798"],"award-info":[{"award-number":["CheSSTaG 769798"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N026322\/1"],"award-info":[{"award-number":["EP\/N026322\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Therapeutics"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Using a preclinical in vivo model of arthritis and the gold standard disease\u2010modifying anti\u2010rheumatic drug, methotrexate, pH\u2010responsive phosphorylcholine polymersomes, elicit both anti\u2010inflammatory and anti\u2010arthritic therapeutic efficacy, while drastically minimizing off\u2010target toxicity. First, the selective accumulation of polymersomes within synovium of inflamed joints. Second, the polymersomes targeting ability toward activated macrophages and synoviocytes, via scavenger receptors, allow their uptake via endocytosis. And third, the polymersomes pH\u2010responsiveness enables the drug escape from early endosomes and hence its intracellular milieu delivery. On\u2010site augment of methotrexate loaded polymersomes enable the complete abrogation of synovial inflammation and prevent the disease progression and severity. Overall, in vitro and in vivo investigations reveal the potential of polymersomes as a promising nanotherapy for treating arthritic inflammation.<\/jats:p>","DOI":"10.1002\/adtp.202100167","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T03:34:41Z","timestamp":1641785681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting Macrophages and Synoviocytes Intracellular Milieu to Augment Anti\u2010Inflammatory Drug Potency"],"prefix":"10.1002","volume":"5","author":[{"given":"Virg\u00ednia M.","family":"Gouveia","sequence":"first","affiliation":[{"name":"Department of Chemistry University College London  London WC1H 0AJ UK"},{"name":"Institute of Physics of Living Systems University College London  London WC1H 0AJ UK"},{"name":"SomaServe Ltd  Babraham Research Campus Cambridge CB22 3AT UK"},{"name":"LAQV REQUIMTE Department of Chemical Sciences Faculty of Pharmacy University of Porto  Porto 4050\u2010313 Portugal"},{"name":"Abel Salazar Biomedical Sciences Institute University of Porto  Porto 4050\u2010313 Portugal"}]},{"given":"Loris","family":"Rizzello","sequence":"additional","affiliation":[{"name":"Department of Chemistry University College London  London WC1H 0AJ UK"},{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Barcelona 08028 Spain"},{"name":"Department of Pharmaceutical Sciences University of Milan  Milan 20133 Italy"},{"name":"National Institute of Molecular Genetics (INGM)  Milan 20122 Italy"}]},{"given":"Bruno","family":"Vidal","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit Institute of Molecular Medicine \u2013 IMM Jo\u00e3o Lobo Antunes Faculty of Medicine University of Lisbon  Lisbon 1649\u2010028 Portugal"}]},{"given":"Claudia","family":"Nunes","sequence":"additional","affiliation":[{"name":"LAQV REQUIMTE Department of Chemical Sciences Faculty of Pharmacy University of Porto  Porto 4050\u2010313 Portugal"}]},{"given":"Alessandro","family":"Poma","sequence":"additional","affiliation":[{"name":"Department of Chemistry University College London  London WC1H 0AJ UK"},{"name":"Division of Biomaterials and Tissue Engineering Eastman Dental Institute Royal Free Hospital UCL Medical School  London NW3 2PF UK"}]},{"given":"Ciro","family":"Lopez\u2010Vasquez","sequence":"additional","affiliation":[{"name":"Department of Chemistry University College London  London WC1H 0AJ UK"},{"name":"Institute of Physics of Living Systems University College London  London WC1H 0AJ UK"}]},{"given":"Edoardo","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Department of Chemistry University College London  London WC1H 0AJ UK"},{"name":"Department of Pharmaceutical Sciences University of Milan  Milan 20133 Italy"},{"name":"National Institute of Molecular Genetics (INGM)  Milan 20122 Italy"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease Queen Square Institute of Neurology University College London  London WC1N 3BG UK"}]},{"given":"Ant\u00f3nio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Abel Salazar Biomedical Sciences Institute University of Porto  Porto 4050\u2010313 Portugal"}]},{"given":"Jo\u00e3o E.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit Institute of Molecular Medicine \u2013 IMM Jo\u00e3o Lobo Antunes Faculty of Medicine University of Lisbon  Lisbon 1649\u2010028 Portugal"},{"name":"Servi\u00e7o de Reumatologia Centro Hospitalar Universit\u00e1rio Lisboa Norte Centro Academico de Medicina de Lisboa  Lisbon 1649\u2010028 Portugal"}]},{"given":"Salette","family":"Reis","sequence":"additional","affiliation":[{"name":"LAQV REQUIMTE Department of Chemical Sciences Faculty of Pharmacy University of Porto  Porto 4050\u2010313 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-6770","authenticated-orcid":false,"given":"Giuseppe","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Department of Chemistry University College London  London WC1H 0AJ UK"},{"name":"Institute of Physics of Living Systems University College London  London WC1H 0AJ UK"},{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Barcelona 08028 Spain"},{"name":"Catalan Institution for Research and Advanced Studies (ICREA)  Barcelona 08010 Spain"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7928"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2015.2159"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27692"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0047"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2333"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328337c95a"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew393"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2006.04.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes113"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142448"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4158"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1303-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.164"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300950"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.04.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2050"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.134684"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-2062-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes278"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem279"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.175"},{"key":"e_1_2_10_25_1","first-page":"1017","volume":"27","author":"Visser K.","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_2_10_26_1","volume-title":"Nanoparticles in Life Sciences and Nanomedicine","author":"Gouveia V. M.","year":"2018"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp400610b"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.97"},{"key":"e_1_2_10_27_3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010459"},{"key":"e_1_2_10_27_4","unstructured":"d) L.Rizzello J. D.Robertson P. M.Elks A.Poma N.Daneshpour T. K.Prajsnar D.Evangelopoulos J. O.Canseco S.Yona H. M.Marriott D. H.Dockrell S. J.Foster B. D.Geest S.De Kokexr T.McHugh S. A.Renshaw B.Giuseppe bioRxiv2017."},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15309b"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2014.09.017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021546"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.38"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568010054022024"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy054"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13061"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.02.001"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2005.07.011"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-7520-1_1"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.02.022"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117100"},{"key":"e_1_2_10_35_3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190920"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11110614"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.110"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601901"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/353695"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000560"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900578"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn102455z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201000083"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01870"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.02.007"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.08.018"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.69.4.522"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1295850"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.01.012"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.669"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2015.2159"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.18.7.723"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704408200"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204169"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-212183"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27494"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY00518G"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33491"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500948"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.137"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.01.012"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107890"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1150-5"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0377"}],"container-title":["Advanced Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adtp.202100167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adtp.202100167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adtp.202100167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:15:43Z","timestamp":1759788943000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adtp.202100167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/adtp.202100167"],"URL":"https:\/\/doi.org\/10.1002\/adtp.202100167","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.22.449368","asserted-by":"object"}]},"ISSN":["2366-3987","2366-3987"],"issn-type":[{"value":"2366-3987","type":"print"},{"value":"2366-3987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"2021-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100167"}}