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To date, ECM\u2010mimetic hydrogels have been widely explored for 3D in vitro disease modeling owing to their bioactive properties that can be further adapted to the biochemical and biophysical properties of native tumors. Gathering on this momentum, herein the current landscape of intrinsically bioactive protein and peptide hydrogels that have been employed for 3D tumor modeling are discussed. Initially, the importance of recreating such microenvironment and the main considerations for generating ECM\u2010mimetic 3D hydrogel in vitro tumor models are showcased. A comprehensive discussion focusing protein, peptide, or hybrid ECM\u2010mimetic platforms employed for modeling cancer cells\/stroma cross\u2010talk and for the preclinical evaluation of candidate anticancer therapies is also provided. Further development of tumor\u2010tunable, proteinaceous or peptide 3D microtesting platforms with microenvironment\u2010specific biophysical and biomolecular cues will contribute to better mimic the in vivo scenario, and improve the predictability of preclinical screening of generalized or personalized therapeutics.<\/jats:p>","DOI":"10.1002\/advs.202003129","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T04:50:59Z","timestamp":1609735859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Proteinaceous Hydrogels for Bioengineering Advanced 3D Tumor Models"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-9663","authenticated-orcid":false,"given":"Barbara","family":"Blanco\u2010Fernandez","sequence":"first","affiliation":[{"name":"Department of Chemistry, CICECO \u2013 Aveiro Institute of Materials, University of Aveiro Campus Universit\u00e1rio de Santiago  Aveiro 3810\u2010193 Portugal"},{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Baldiri Reixac 10\u201312 Barcelona 08028 Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-2493","authenticated-orcid":false,"given":"V\u00edtor M.","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO \u2013 Aveiro Institute of Materials, University of Aveiro Campus Universit\u00e1rio de Santiago  Aveiro 3810\u2010193 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-8874","authenticated-orcid":false,"given":"Elisabeth","family":"Engel","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology  Baldiri Reixac 10\u201312 Barcelona 08028 Spain"},{"name":"Materials Science and Metallurgical Engineering Polytechnical University of Catalonia (UPC)  Eduard Maristany 16 Barcelona 08019 Spain"},{"name":"CIBER en Bioingenier\u00eda Biomateriales y Nanomedicina CIBER\u2010BBN  Madrid 28029 Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-3765","authenticated-orcid":false,"given":"Jo\u00e3o F.","family":"Mano","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO \u2013 Aveiro Institute of Materials, University of Aveiro Campus Universit\u00e1rio de Santiago  Aveiro 3810\u2010193 Portugal"}]}],"member":"311","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxy072"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0452"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1635"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0495-5"},{"key":"e_1_2_9_5_1","first-page":"114","volume":"6","author":"Mak I.","year":"2014","journal-title":"Am. 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