{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:42:16Z","timestamp":1775022136517,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81761148028"],"award-info":[{"award-number":["81761148028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801704"],"award-info":[{"award-number":["81801704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21773026"],"award-info":[{"award-number":["21773026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18YF1415300"],"award-info":[{"award-number":["18YF1415300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19410740200"],"award-info":[{"award-number":["19410740200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20520710300"],"award-info":[{"award-number":["20520710300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19XD1400100"],"award-info":[{"award-number":["19XD1400100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Design of new nanoplatforms that integrates multiple imaging and therapeutic components for precision cancer nanomedicine remains to be challenging. Here, a facile strategy is reported to prepare polydopamine (PDA)\u2010coated molybdenum disulfide (MoS<jats:sub>2<\/jats:sub>) nanoflakes as a nanocarrier to load dual drug cisplatin (Pt) and 1\u2010methyl\u2010tryptophan (1\u2010MT) for precision tumor theranostics. Preformed MoS<jats:sub>2<\/jats:sub> nanoflakes are coated with PDA, modified with methoxy\u2010polyethylene glycol (PEG)\u2010amine, and loaded with 1\u2010MT and Pt. The formed functional 1\u2010MT\u2010Pt\u2010PPDA@MoS<jats:sub>2<\/jats:sub> (the second P stands for PEG) complexes exhibit good colloidal stability and photothermal conversion efficiency (47.9%), dual pH\u2010, and photothermal\u2010sensitive drug release profile, and multimodal thermal, computed tomography and photoacoustic imaging capability. Due to the respective components of Pt, MoS<jats:sub>2<\/jats:sub>, and 1\u2010MT that can block the immune checkpoint associated to tumoral indoleamine 2,3\u2010dioxygenase\u2010induced tryptophan metabolism, tri\u2010mode chemo\u2010photothermo\u2010immunotherapy of tumors can be realized. In particular, under the near infrared laser irradiation, fast release of both drugs can be facilitated to achieve cooperative tumor therapy effect, and the combined immunogenic cell death induced by the dual\u2010mode chemo\u2010photothermo treatment and the 1\u2010MT\u2010induced immune checkpoint blockade can boost enhanced antitumor immune response to generate significant cytotoxic T\u00a0cells for tumor killing. The developed 1\u2010MT\u2010Pt\u2010PPDA@MoS<jats:sub>2<\/jats:sub> complexes may be used as an intelligent nanoplatform for cooperative precision imaging\u2010guided combinational tumor therapy.<\/jats:p>","DOI":"10.1002\/advs.202100165","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T05:04:07Z","timestamp":1623992647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging\u2010Guided Tri\u2010Mode Chemo\u2010Photothermo\u2010Immunotherapy"],"prefix":"10.1002","volume":"8","author":[{"given":"Wei","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry, Chemical Engineering and Biotechnology Donghua University  Shanghai 201620 P. R. China"},{"name":"Department of Gynecology and Obstetrics XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200092 P. R. China"}]},{"given":"Tingting","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry, Chemical Engineering and Biotechnology Donghua University  Shanghai 201620 P. R. China"}]},{"given":"Du","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry, Chemical Engineering and Biotechnology Donghua University  Shanghai 201620 P. R. China"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry, Chemical Engineering and Biotechnology Donghua University  Shanghai 201620 P. R. China"}]},{"given":"Lingxi","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200092 P. R. China"}]},{"given":"Xipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200092 P. R. China"}]},{"given":"Yulin","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory for Ultrafine Materials of Ministry of Education State Key Laboratory of Bioreactor Engineering Engineering Research Center for Biomedical Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 P. R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-6645","authenticated-orcid":false,"given":"Xiangyang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry, Chemical Engineering and Biotechnology Donghua University  Shanghai 201620 P. R. China"},{"name":"CQM\u2010Centro de Quimica da Madeira Universidade da Madeira  Funchal 9020\u2010105 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-0854","authenticated-orcid":false,"given":"Mingwu","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry, Chemical Engineering and Biotechnology Donghua University  Shanghai 201620 P. R. China"}]}],"member":"311","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909285"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100899"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b04757"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700891"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1703726"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan3682"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.201700224"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500439"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b10144"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c00910"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100851"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18546-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3043856"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407190-2.00007-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02765"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22242"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201707249"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.4161\/onci.21716"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04371"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-017-0377-x"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0479-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801527"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801122"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201703588"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05425"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600923"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110551"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.10.020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c00082"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201900282"},{"key":"e_1_2_8_21_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.05.006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06267"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03473-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120159"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00262"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/ab94dc"},{"key":"e_1_2_8_26_3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01918"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07212"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c08074"},{"key":"e_1_2_8_27_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c08112"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.24073"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914768"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.073"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b01807"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b03371"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2925"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c07721"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01651-9"},{"key":"e_1_2_8_34_3","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.11.13434"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202100165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202100165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202100165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:19:45Z","timestamp":1759774785000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202100165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,18]]},"references-count":51,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/advs.202100165"],"URL":"https:\/\/doi.org\/10.1002\/advs.202100165","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,18]]},"assertion":[{"value":"2021-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100165"}}