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To address this issue, a PAA\u2010based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segments on PAA prevent the electrostatic repulsion among the ionized carboxyl groups and absorbed TA to form coacervates. The absorbed TA provides solid adhesion to dry and wet substrates via multifarious interactions, which endows the coacervate with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. This coacervate achieves desirable self\u2010healing and extensible properties suitable for frequently moving joints. These investigations prove that the coacervate has strong antibacterial activity, facilitates\u00a0fibroblast migration, and modulates M1\/M2 polarization of macrophages. In vivo hemorrhage experiments further confirm that the coacervate dramatically shortens the hemostatic time from hundreds to tens of seconds. In addition, full\u2010thickness skin defect experiments demonstrate that the coacervate achieves the best therapeutic effect by significantly promoting collagen deposition, angiogenesis, and epithelialization. These results demonstrate that a PAA\u2010based coacervate hydrogel is a promising wound dressing for medical translation.<\/jats:p>","DOI":"10.1002\/advs.202207352","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T23:58:10Z","timestamp":1681516690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Bioinspired Polyacrylic Acid\u2010Based Dressing: Wet Adhesive, Self\u2010Healing, and Multi\u2010Biofunctional Coacervate Hydrogel Accelerates Wound Healing"],"prefix":"10.1002","volume":"10","author":[{"given":"Lingshuang","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture, Textile, and Biomass Sciences Southwest University  Chongqing 400715 China"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture, Textile, and Biomass Sciences Southwest University  Chongqing 400715 China"}]},{"given":"Ga","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture, Textile, and Biomass Sciences Southwest University  Chongqing 400715 China"}]},{"given":"Jianfeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Botnar Research Centre Nuffield Department of Orthopedics, Rheumatology, and Musculoskeletal Sciences University of Oxford  Headington Oxford OX3 7LD UK"}]},{"given":"Mohammad\u2010Ali","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University Medical Center Groningen University of Groningen  Antonius Deusinglaan 1 Groningen 9713 AV Netherlands"}]},{"given":"Subhas C.","family":"Kundu","sequence":"additional","affiliation":[{"name":"3Bs Research Group I3Bs \u2014 Research Institute on Biomaterials, Biodegradables, and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Barco Guimaraes 4805\u2010017 Portugal"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3Bs Research Group I3Bs \u2014 Research Institute on Biomaterials, Biodegradables, and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Barco Guimaraes 4805\u2010017 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-6435","authenticated-orcid":false,"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture, Textile, and Biomass Sciences Southwest University  Chongqing 400715 China"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology College of Sericulture, Textile, and Biomass 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